Divalent cations in essential hypertension. Relations between serum ionized calcium, magnesium, and plasma renin activity.
Divalent cations in essential hypertension. Relations between serum ionized calcium, magnesium, and plasma renin activity.
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DOI：
10.1056/nejm198310133091504
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发表时间：
1983-10
期刊：
影响因子：
--
通讯作者：
L. Resnick;J. Laragh;J. Sealey;M. Alderman
中科院分区：
文献类型：
--
作者：
L. Resnick;J. Laragh;J. Sealey;M. Alderman
我们研究了102例正常血压患者和98例原发性高血压患者血浆肾素活性与血清离子钙和镁水平的关系，这些患者被分为低肾素组、正常肾素组和高肾素组。低肾素高血压患者的血清镁水平高于正常肾素高血压患者（P <0.025）或正常血压对照组（P <0.005，P <0.05），而高肾素高血压患者的血清镁水平低于正常肾素高血压患者（P <0.025）。与此相反，低肾素高血压患者的血清离子钙水平低于正常肾素高血压患者（P <0.001，P <0.05，分别）或正常血压对照组（P <0.001，P <0.05，分别），高肾素高血压患者的血清离子钙水平高于正常肾素高血压患者（P <0.001，P <0.05，分别）。原发性高血压患者血浆肾素活性与血清镁水平呈持续负相关（r =-0.60，P <0.001），与血清离子钙水平呈正相关（r = 0.44，P <0.001）。因此，高血压中的血浆肾素活性可能反映或有助于跨细胞膜的钙和镁通量的变化。
We studied the relation of plasma renin activity to serum levels of ionized calcium and magnesium in 102 normotensive patients and in 98 patients with essential hypertension who were divided into low-renin, normal-renin, and high-renin groups. Serum magnesium levels were higher in patients with low-renin hypertension and lower in patients with high-renin hypertension than in those with normal-renin hypertension (P less than 0.025 for both comparisons) or in normotensive controls (P less than 0.005, P less than 0.05, respectively). In contrast, serum levels of ionized calcium were lower in patients with low-renin hypertension and higher in patients with high-renin hypertension than in those with normal-renin hypertension (P less than 0.001, P less than 0.05, respectively) or in normotensive controls (P less than 0.001, P less than 0.05, respectively). Altogether, the range of plasma renin activity in essential hypertension shows a continuous negative correlation with the serum magnesium level (r = -0.60, P less than 0.001) and a positive correlation with the serum ionized calcium level (r = 0.44, P less than 0.001). Accordingly, plasma renin activity in hypertension may reflect or contribute to changes in calcium and magnesium fluxes across cell membranes.