Protective Effect of Gabapentin on N-Methyl-D-aspartate-Induced Excitotoxicity in Rat Hippocampal CA1 Neurons
Protective Effect of Gabapentin on N-Methyl-D-aspartate-Induced Excitotoxicity in Rat Hippocampal CA1 Neurons
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DOI：
10.1254/jphs.08067sc
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发表时间：
2009-01-01
影响因子：
3.5
通讯作者：
Kim, Chang-Ju
中科院分区：
文献类型：
--
作者：
Kim, Young-Sick;Chang, Hyun-Kyung;Kim, Chang-Ju
加巴喷丁是一种抗惊厥药，但也被用于缓解神经性疼痛的痛觉过敏。本研究探讨加巴喷丁对n -甲基- d -天冬氨酸（NMDA）诱导的大鼠海马CA1神经元兴奋性毒性的保护作用。加巴喷丁预处理降低了NMDA暴露对培养海马切片的神经元损伤程度。膜片钳研究发现，加巴喷丁显著抑制解离海马CA1神经元中NMDA受体激活的离子电流，从而抑制谷氨酸诱导的神经元损伤。这些结果表明，加巴喷丁可能通过抑制NMDA受体激活的离子电流对谷氨酸诱导的神经元损伤发挥保护作用。
Gabapentin was developed as an anticonvulsant, but has also been used to alleviate hyperalgesia in neuropathic pain. In this study, the protective effect of gabapentin against N-methyl-D-aspartate (NMDA)-induced excitotoxicity in rat hippocampal CA1 neurons was investigated. Pre-treatment with gabapentin reduced the degree of neuronal damage induced by NMDA exposure in cultured hippocampal slices. Patch-clamp studies revealed that gabapentin significantly inhibited the NMDA receptor-activated ion current in dissociated hippocampal CA1 neurons, resulting in suppression of glutamate-induced neuronal injury. These results show that gabapentin may exert protective effects against glutamate-induced neuronal injury at least in part by inhibiting the NMDA receptor-activated ion current.