Polymorphonuclear leukocyte dysfunction associated with feline leukaemia virus infection.
Polymorphonuclear leukocyte dysfunction associated with feline leukaemia virus infection.
复制标题
与猫白血病病毒感染相关的多形核白细胞功能障碍。
DOI：
10.1099/0022-1317-67-10-2113
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Olsen,RG
中科院分区：
文献类型：
--
作者：
Lewis,MG;Duska,GO;Stiff,MI;Lafrado,LJ;Olsen,RG
本文研究了正常猫和猫白血病病毒（FeLV）感染猫外周血多形核白细胞（PMN）富集（>95%）的荧光特性。与正常年龄匹配的对照组相比，FeLV感染猫的PMN荧光反应显著降低（P< 0.001）。与对照细胞相比，用FeLV感染的猫血清处理的正常PMN表现出抑制的反应。用正常血清补充的感染猫血清的滴定显示，随着感染猫血清浓度的增加，化学发光受到可滴定的抑制。然而，从FeLV感染的猫与正常血清治疗的PMN显示出轻微的化学发光增加，在自体血清中相同的细胞。将灭活的FeLV加入到正常PMN中可引起化学发光的可滴定降低。
The chemiluminescent characteristics of enriched (>95%) peripheral blood polymorphonuclear leukocyte populations (PMN) from normal and feline leukaemia virus (FeLV)-infected cats were investigated. FeLV-infected cats demonstrated a significantly lower (P< 0.001) PMN chemiluminescent response when compared to the response of normal age-matched controls. Normal PMN treated with FeLV-infected cat serum exhibited a depressed response in comparison to control cells. A titration of serum from infected cats supplemented with normal serum revealed a titratable suppression of chemiluminescence with increasing concentration of serum from the infected cats. However, PMN from FeLV-infected cats treated with normal serum displayed a slight increase in chemiluminescence over the same cells in autologous serum. The addition of inactivated FeLV to normal PMN caused a titratable decrease in chemiluminescence.