Plasma visfatin levels and mRNA expression of visfatin in peripheral blood mononuclear cells and peripheral blood monocyte-derived macrophages from normal weight females with polycystic ovary syndrome.
Plasma visfatin levels and mRNA expression of visfatin in peripheral blood mononuclear cells and peripheral blood monocyte-derived macrophages from normal weight females with polycystic ovary syndrome.
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正常体重多囊卵巢综合征女性血浆内脂素水平及外周血单核细胞和外周血单核细胞源性巨噬细胞内脂素 mRNA 表达
DOI：
10.3892/etm.2014.1556
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发表时间：
2014-05
影响因子：
2.7
通讯作者：
Xu L
中科院分区：
文献类型：
--
作者：
Zhang J;Zhou L;Tang L;Xu L
Polycystic ovary syndrome (PCOS) is a common reproductive endocrinology disease, however, an explicit etiology is not known. Insulin resistance (IR) appears to be central to the pathogenesis of PCOS and inflammation may be significant in the pathogenesis of IR in PCOS. The aims of the present study were to investigate the plasma visfatin level and the gene expression of visfatin in peripheral blood mononuclear cells (PBMCs) and peripheral blood monocyte-derived macrophages (PBMMs) from PCOS patients, in addition to investigating the association between PCOS and IR. A total of 21 PCOS patients and 21 control subjects were enrolled in the study; the homeostasis model assessment of insulin resistance (HOMA-IR) was considered to be a stratified method for establishing the subgroups. Fasting blood samples were collected and the levels of sex hormones, insulin, glucose, blood lipids and visfatin were measured. In addition, visfatin gene expression levels in PBMCs and PBMMs were assessed using quantitative polymerase chain reaction. The plasma visfatin and gene expression levels of visfatin in PBMCs and PBMMs were not observed to increase in the normal weight PCOS and normal weight IR patients. Furthermore, plasma visfatin levels did not correlate with the normal weight PCOS patients or the normal weight IR patients per se. Further investigation into the role of visfatin in the pathogenesis of PCOS or IR should examine macrophages in the tissues, rather than macrophages in the peripheral blood.
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影响因子：
5.8
作者：
Boulman, N;Levy, Y;Blumenfeld, Z
通讯作者：
Blumenfeld, Z
影响因子：
6.7
作者：
Plati, Ekaterina;Kouskouni, Evangelia;Baka, Stavroula
通讯作者：
Baka, Stavroula
影响因子：
6.1
作者：
Kowalska, Irina;Straczkowski, Marek;Gorska, Maria
通讯作者：
Gorska, Maria
影响因子：
4.4
作者：
Sun, Qin;Li, Ling;Yang, Gangyi
通讯作者：
Yang, Gangyi
影响因子：
5.8
作者：
Tan, Bee K.;Chen, Jing;Randeva, Harpal S.
通讯作者：
Randeva, Harpal S.