The duration of severe insulin omission is the factor most closely associated with the microvascular complications of Type 1 diabetic females with clinical eating disorders.
The duration of severe insulin omission is the factor most closely associated with the microvascular complications of Type 1 diabetic females with clinical eating disorders.
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DOI：
10.1002/eat.20498
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发表时间：
2008-04
期刊：
影响因子：
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通讯作者：
M. Takii;Y. Uchigata;S. Tokunaga;Naoko Amemiya;N. Kinukawa;T. Nozaki;Y. Iwamoto;C. Kubo
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文献类型：
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作者：
M. Takii;Y. Uchigata;S. Tokunaga;Naoko Amemiya;N. Kinukawa;T. Nozaki;Y. Iwamoto;C. Kubo
目的探讨1型糖尿病女性患者饮食障碍与视网膜病变和肾病的相关性。方法参与者为109名1型糖尿病女性，通过DSM-IV的结构化临床访谈诊断为临床进食障碍（神经性贪食症[n = 70]，暴食症[n = 28]，神经性厌食症[n = 7]和未另行说明的进食障碍[n = 4]）。筛选视网膜病变和肾病，并调查人口统计学、医学和饮食失调相关因素。对各种并发症的相关因素进行Logistic回归分析。结果在多变量回归分析中，严重胰岛素缺失的持续时间和1型糖尿病的持续时间与视网膜病变（比值比分别为1.35和1.23）和肾病（比值比分别为1.35和1.21）显著相关。结论多因素分析显示，在与进食障碍相关的各种行为问题因素中，严重胰岛素缺失的持续时间是与1型糖尿病女性患者视网膜病变和肾病最密切相关的因素。这一发现可能有助于故意漏服胰岛素的患者意识到漏服胰岛素的医疗风险。
OBJECTIVE To investigate which features of eating disorders are associated with retinopathy and nephropathy in Type 1 diabetic females with clinical eating disorders. METHOD Participants were 109 Type 1 diabetic females with clinical eating disorders diagnosed by the structured clinical interview for DSM-IV (bulimia nervosa [n = 70], binge-eating disorder [n = 28], anorexia nervosa [n = 7], and eating disorder not otherwise specified [n = 4]). Retinopathy and nephropathy were screened and demographic, medical, and eating disorder related factors were investigated. To identify the factors associated with each complication, logistic regression analysis was done. RESULTS Duration of severe insulin omission and duration of Type 1 diabetes were significantly associated with retinopathy (odds ratios = 1.35 and 1.23, respectively) and nephropathy (odds ratio = 1.35 and 1.21, respectively) in multivariate regression analyses. CONCLUSION Of the various problematic behavioral factors related to eating disorders, the duration of severe insulin omission was the factor most closely associated with the retinopathy and nephropathy of Type 1 diabetic females with clinical eating disorders by multivariate analysis. This finding may help patients who deliberately omit insulin become aware of medical risk of insulin omission.