Genetic Architecture of Declarative Memory: Implications for Complex Illnesses
Genetic Architecture of Declarative Memory: Implications for Complex Illnesses
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DOI：
10.1177/1073858411415113
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发表时间：
2012-10-01
期刊：
影响因子：
5.6
通讯作者：
Glahn, David C.
中科院分区：
文献类型：
--
作者：
Bearden, Carrie E.;Karlsgodt, Katherine H.;Glahn, David C.
为什么记忆能力在个体和认知领域之间差异如此之大？虽然记忆功能是高度可遗传的，但究竟什么是遗传的呢？在这里，我们回顾了记忆功能不同方面的共同和部分独立遗传的贡献的证据。我们首先讨论长期记忆的评估及其潜在的神经和分子基础。然后，我们考虑了记忆个体差异背后的专业基因和通才基因的证据，表明将记忆切割成不同的子组件可能会产生有关其遗传结构的重要信息。最后，我们回顾了来自复杂和单基因疾病的证据，这些证据为人类记忆功能遗传基础的分子机制提供了见解。
Why do memory abilities vary so greatly across individuals and cognitive domains? Although memory functions are highly heritable, what exactly is being genetically transmitted? Here we review evidence for the contribution of both common and partially independent inheritance of distinct aspects of memory function. We begin by discussing the assessment of long-term memory and its underlying neural and molecular basis. We then consider evidence for both specialist and generalist genes underlying individual variability in memory, indicating that carving memory into distinct subcomponents may yield important information regarding its genetic architecture. And finally we review evidence from both complex and single-gene disorders, which provide insight into the molecular mechanisms underlying the genetic basis of human memory function.