Synthesis and reactions of the pestalotiopsin skeleton
Synthesis and reactions of the pestalotiopsin skeleton
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DOI：
10.1002/anie.200801900
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发表时间：
2008-01-01
影响因子：
16.6
通讯作者：
Procter, David J.
中科院分区：
文献类型：
--
作者：
Baker, Thomas M.;Edmonds, David J.;Procter, David J.
家族关系：pestalotiopsin框架已经通过使用SmI 2介导的环化和Nozaki-Hiyama-Kishi偶联分别构建靶标的四元环和九元环来构建。首次合成进入先前未开发的taedolidol家族的天然产物已通过pestalotiopsin骨架的立体选择性，酸介导的环化实现。© 2008 Wiley-VCH Verlag GmbH & Co. KGaA。
(Chemical Equation Presented) Family ties: The pestalotiopsin framework has been constructed by using a SmI2-mediated cyclization and a Nozaki-Hiyama-Kishi coupling to construct the four-and nine-membered rings of the target, respectively. The first synthetic entry into the previously unexplored taedolidol family of natural products has been achieved through a stereoselective, acid-mediated cyclization of the pestalotiopsin skeleton.© 2008 Wiley-VCH Verlag GmbH & Co. KGaA.