Comparison of prognostic values between combined immunohistochemical score of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, Ki-67 and the corresponding gene expression score in breast cancer
Comparison of prognostic values between combined immunohistochemical score of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, Ki-67 and the corresponding gene expression score in breast cancer
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DOI：
10.1038/modpathol.2012.151
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发表时间：
2013-01-01
期刊：
影响因子：
7.5
通讯作者：
Iwase, Hirotaka
中科院分区：
文献类型：
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作者：
Yamamoto-Ibusuki, Mutsuko;Yamamoto, Yutaka;Iwase, Hirotaka
在乳腺癌的临床诊断中，常规使用具有雌激素受体（ER）、孕激素受体（PgR）、人表皮生长因子受体2（HER 2）和Ki-67的免疫组织化学组，并且它们已被提议用于将乳腺肿瘤分类为不同的亚型。福尔马林固定石蜡包埋材料的基因表达分析最近也变得广泛使用，但与这四个免疫组化面板相比，相应的基因面板的预后价值从未测试过。我们使用四个免疫组化组的半定量数据（Ku-IHC 4评分）独立评估了5年复发风险估计评分，并将其与235例原发性浸润性乳腺癌患者的福尔马林固定石蜡包埋标本的四个基因表达谱（Ku-FFPE 4评分）的结果进行了比较。在通过经典临床参数分析的多变量模型中，Ku-IHC 4评分是除Ku-FFPE 4评分之外的复发的独立预测因子（Ku-IHC 4评分vs Ku-FFPE 4评分;卡方（2）：14.2 vs 2.5，P：0.0002 vs 0.11）。当使用根据大约计算的5年复发率确定的阈值将患者分为高、中、低风险组时，Kaplan-Meier分析显示三组之间Ku-IHC 4评分存在显著差异（对数秩，P
In the clinical diagnosis of breast cancer, immunohistochemistry panels with estrogen receptor (ER), progesterone receptor (PgR), human epidermal growth factor receptor 2 (HER2) and Ki-67 are routinely used, and they have been proposed for the classification of breast tumors into distinct subtypes. Gene expression analysis with formalin-fixed paraffin-embedded material have also become widely available recently, but the prognostic values of corresponding gene panels compared with these four immunohistochemical panels had never tested. We independently evaluated the 5-year relapse risk-estimation scores using semiquantitative data of four immunohistochemical panels (Ku-IHC4 score) and compared these with the results of four-gene expression profiling of formalin-fixed paraffin-embedded specimens (Ku-FFPE4 score) in a consecutive series of 235 primary invasive breast cancer patients. Ku-IHC4 score was revealed to be an independent predictor of recurrence other than Ku-FFPE4 score in a multivariate model analyzed by classical clinical parameters (Ku-IHC4 score vs Ku-FFPE4 score; chi(2): 14.2 vs 2.5, P: 0.0002 vs 0.11). When patients were trichotomized into high-, intermediate- and low-risk groups using the thresholds determined from the approximately calculated 5-year relapse rate, Kaplan-Meier analyses showed a significant difference among the three groups in Ku-IHC4 score (log-rank, P