Middle ear overpressure treatment of endolymphatic hydrops in guinea pigs
Middle ear overpressure treatment of endolymphatic hydrops in guinea pigs
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DOI：
10.1159/000276915
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发表时间：
1997-03-01
期刊：
影响因子：
--
通讯作者：
Kimura, RS
中科院分区：
文献类型：
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作者：
Sakikawa, Y;Kimura, RS
在内淋巴管堵塞后立即将豚鼠置于压力室内外并连续暴露于 49.2 cm H2O 超压下 24 小时，与对照组相比，内淋巴水肿的程度没有显着差异，尽管外部治疗组有轻微的体积减少和体积增加的迹象。室内治疗组，外耳道内压力增加 49.2 cm H2O，每次 1 小时，每天两次，持续 2 周，在室外治疗组中，可显着抑制积水的发展。后一个结果支持通过外耳道施加压力作为梅尼埃病治疗的优点。
Guinea pigs placed outside or inside a pressure chamber and exposed to 49.2 cm H2O overpressure continuously for 24 h immediately after blockage of the endolymphatic duct showed no significant difference in the magnitude of endolymphatic hydrops when compared to controls, although there was a slight indication of a volume decrease in the outside-treatment group and an increase in the. inside-treatment group, A pressure increase of 49.2 cm H2O in the external auditory canal for 1 h twice a day for 2 weeks outside the chamber significantly inhibited the development of hydrops. The latter result supports the merit of pressure application through the external auditory canal as a treatment for Meniere's disease.