Comparison of single-breath and tidal breathing exhaled nitric oxide levels in infants
Comparison of single-breath and tidal breathing exhaled nitric oxide levels in infants
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DOI：
10.1183/09031936.04.00084604
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发表时间：
2004-03-01
影响因子：
24.3
通讯作者：
Stick, SM
中科院分区：
文献类型：
--
作者：
Franklin, PJ;Turner, SW;Stick, SM
为比较潮气呼吸法（TB）和单次呼吸法（SB）测定婴幼儿呼出气一氧化氮（FENO）的差异，对71例反复喘息（32例）、反复咳嗽（16例）和无症状（23例）的婴幼儿进行了FENO测定。对于TB测量，将5次呼吸收集到气体采样袋中（离线储液器采样）。SB法是在快速胸腹联合技术基础上改进而来。研究了两种方法之间的一致性，并将两种方法用于比较有症状和无症状婴儿的FENO。s（-1））。有中度相关性（r=0.60），但使用TB和SB方法的水平之间的协议差。健康儿童和喘息儿童之间FENO的显着差异，发现使用SB，但不是TB的方法。由于较低的呼气流量和减少鼻腔一氧化氮污染的单呼吸技术可能比潮汐呼吸法检测呼出的一氧化氮之间的差异更敏感，没有呼吸系统症状的婴儿。
The aim of this study was to compare two different methods, tidal breathing (TB) and single-breath (SB), for measuring fractional exhaled nitric oxide (FENO) in infants.FENO was measured in 71 infants with either recurrent wheeze (n=32), recurrent cough (n=16) or no symptoms (healthy, n=23) using both methods. For TB measurements five breaths were collected into a gas sampling bag (off-line reservoir sampling). The SB method was modified from the raised volume rapid thoraco-abdominal technique. Agreement between the two methods was investigated and both methods were used to compare FENO in infants with and without symptoms.Flow dependence of SB FENO was demonstrated using two expiratory flows (I I and 40 mL(.)s(-1)). There was a moderate correlation (r=0.60) but poor agreement between levels using the TB and SB methods. A significant difference in FENO between healthy children and children with wheeze was found using the SB but not the TB method.Due to lower expiratory flow and reduced nasal nitric oxide contamination the single-breath technique may be more sensitive than the tidal breathing method for detecting differences in exhaled nitric oxide between infants with and without respiratory symptoms.