Abnormal coronary vascular response to exercise in dogs with severe right ventricular hypertrophy.
Abnormal coronary vascular response to exercise in dogs with severe right ventricular hypertrophy.
复制标题
严重右心室肥大的狗对运动的冠状血管反应异常。
DOI：
10.1172/jci110160
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Vatner,SF
中科院分区：
文献类型：
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作者：
Murray,PA;Vatner,SF
对正常犬和慢性（5-6个月）肺动脉狭窄诱导的右心室（RV）肥大犬在剧烈自发运动期间进行了右冠状动脉血流量、主动脉和右心室（RV）压力和心率的无线遥测测量。在固定肺动脉狭窄的情况下，右室肥厚犬在运动过程中动脉压降低（P <0.01）。在这些条件下，运动增加右冠状动脉血流量和右冠状动脉血管阻力减少右室肥厚的狗与正常相比（P <0.05）。当运动过程中动脉压保持在运动前水平时，右心室肥大犬的右冠状动脉血流没有出现这种衰减反应。然而，无论运动期间动脉压的变化如何，所有右心室肥大的犬均表现出显著的运动后冠状动脉充血（P <0.01），表明运动期间右心室肥大的灌注不足。这些结果意味着严重肥大的右心室的冠状动脉循环在面对运动代谢需求升高时提供足够营养供应的能力存在根本缺陷。
Measurements of right coronary artery blood flow, aortic and right ventricular (RV) pressures and heart rate were radiotelemetered during strenuous, spontaneous exercise in normal dogs and dogs with severe RV hypertrophy induced by chronic (5-6 mo) pulmonary artery stenosis. With fixed pulmonic stenosis, dogs with RV hypertrophy exhibited a decrease (P less than 0.01) in arterial pressure during exercise. Under these conditions, exercise increased right coronary artery blood flow and decreased right coronary vascular resistance less (P less than 0.05) in dogs with RV hypertrophy compared with normal. This attenuated response of right coronary artery blood flow of dogs with RV hypertrophy was not observed when arterial pressures remained at preexercise values during exercise. However, regardless of changes in arterial pressures during exercise, all dogs with RV hypertrophy demonstrated a striking postexercise coronary hyperemia (P less than 0.01), suggesting a perfusion deficit of the hypertrophied right ventricle during exercise. These results imply a fundamental defect in the ability of the coronary circulation of the severely hypertrophied right ventricle to provide sufficient nutrient supply in the face of elevated metabolic demands of exercise.