Variations in the preproghrelin gene correlate with higher body mass index, fat mass, and body dissatisfaction in young Japanese women
Variations in the preproghrelin gene correlate with higher body mass index, fat mass, and body dissatisfaction in young Japanese women
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DOI：
10.1093/ajcn/86.1.25
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发表时间：
2007-07-01
影响因子：
7.1
通讯作者：
Komaki, Gen
中科院分区：
文献类型：
--
作者：
Ando, Tetsuya;Ichimaru, Yuhei;Komaki, Gen
背景资料：Ghrelin是一种内源性肽，可刺激生长激素分泌，增强食欲，增加体重，并可能在进食障碍中发挥作用。目的：目的是确定是否有任何前体基因变异与人体测量指标，循环ghrelin，脂质浓度，胰岛素抵抗，或心理措施有关的年轻女性进食障碍。设计：这项横断面研究比较了前促生长素基因型之间的结果指标。该研究的参与者包括264名日本女性[平均（+/- SD）年龄为20.4 +/- 0.7的大学生]，没有饮食失调史。主要结果是对进食障碍量表-2（EDI-2）的反应，人体测量，抑郁和焦虑的测量，以及酰化或去酰基ghrelin，血脂，葡萄糖和胰岛素的空腹血液浓度。两个次要等位基因频率> 0.05的单核苷酸多态性（SNP）-Leu 72 Met采用外显子2的（408 C -> A）SNP和内含子2的3056 T-C SNP进行关联分析。3056 C等位基因与较高的酰化ghrelin浓度显著相关（P = 0.0021），体重（P = 0.011）、体重指数（P = 0.007）、脂肪量（P = 0.012）、腰围（P = 0.008）和皮褶厚度（P = 0.011）以及较低的HDL-胆固醇浓度（P = 0.02）。有趣的是，3056 C等位基因与EDI-2的瘦身驱动力-身体不满（DT-BD）子量表的评分升高相关（P = 0.003）。结论：我们的研究结果表明，前促生长素基因3056 T-> C SNP与基础促生长素浓度的变化以及与饮食失调和肥胖相关的身体和心理变量相关。
Background: Ghrelin is an endogenous peptide that stimulates growth hormone secretion, enhances appetite, and increases body weight and may play a role in eating disorders.Objective: The purpose was to determine whether any preproghrelin gene variants are associated with anthropometric measures, circulating ghrelin, lipid concentrations, insulin resistance, or psychological measures relevant to eating disorders in young women.Design: This cross-sectional study compared outcome measures between preproghrelin genotypes. The participants in the study included 264 Japanese women [university students with a mean ( +/- SD) age of 20.4 +/- 0.7] with no history of eating disorders. The main outcomes were responses to the Eating Disorder Inventory-2 (EDI-2), anthropometric measures, measures of depression and anxiety, and fasting blood concentrations of acylated or desacyl ghrelin, lipids, glucose, and insulin.Results: Two single nucleotide polymorphisms (SNPs) whose minor allele frequencies were > 0.05-the Leu72Met (408 C -> A) SNP in exon 2 and the 3056 T-C SNP in intron 2-were used for association analysis. The 3056C allele was significantly associated with a higher acylated ghrelin concentration (P = 0.0021), body weight (P = 0.011), body mass index (P = 0.007), fat mass (P = 0.012), waist circumference (P = 0.008), and skinfold thickness (P = 0.011) and a lower HDL-cholesterol concentration (P = 0.02). Interestingly, the 3056C allele was related to elevated scores in the Drive for Thinness-Body Dissatisfaction (DT-BD) subscale of the EDI-2 (P = 0.003).Conclusion: Our findings suggest that the preproghrelin gene 3056T -> C SNP is associated with changes in basal ghrelin concentrations and physical and psychological variables related to eating disorders and obesity.