The effects of finasteride (Proscar) on hair growth, hair cycle stage, and serum testosterone and dihydrotestosterone in adult male and female stumptail macaques (Macaca arctoides).
The effects of finasteride (Proscar) on hair growth, hair cycle stage, and serum testosterone and dihydrotestosterone in adult male and female stumptail macaques (Macaca arctoides).
复制标题
非那雄胺（保列治）对成年雄性和雌性短尾猴（Macaca arctoides）毛发生长、毛发周期阶段以及血清睾酮和二氢睾酮的影响。
DOI：
10.1210/jcem.79.4.7962310
复制
发表时间：
1994
期刊：
影响因子：
--
通讯作者：
B. Pikounis
中科院分区：
文献类型：
--
作者：
L. Rhodes;J. Harper;H. Uno;G. Gaito;J. Audette;S. Kurata;C. Berman;R. Primka;B. Pikounis
非那雄胺是一种 5 α 还原酶抑制剂，对六只雄性和五只雌性短尾猕猴口服给药（1 毫克/千克·天）6 个月。在同一时间段内将载体给予五只雄性和五只雌性动物。每 1-2 个月定期测量前额头皮 1 英寸 2 区域的头发重量，并收集血清用于测量睾酮和二氢睾酮。此外，在治疗前和治疗后6个月进行头皮活检，以评估毛囊的微形态。结果显示，非那雄胺治疗后男性和女性血清二氢睾酮水平均显着降低（60-70%）。与对照组相比，男性和女性在治疗期间平均头发重量均出现统计学显着增加（P = 0.034）。此外，与非那雄胺治疗的动物的基线相比，平均毛囊长度（在头皮活检中进行组织学测量）有统计学上的显着增加（P = 0.028）。这些数据表明，抑制短尾猕猴中的 5α-还原酶可以逆转雄性和雌性动物随年龄增长而出现的秃顶现象。
Finasteride, a 5 alpha-reductase inhibitor, was administered orally (1 mg/kg.day) for 6 months to six male and five female stumptail macaques. Vehicle was given to five male and five female animals over the same period of time. Hair weights in a defined 1-in.2 area of frontal scalp were measured periodically every 1-2 months, and serum was collected for measurement of testosterone and dihydrotestosterone. In addition, scalp biopsies were taken before and 6 months after treatment to evaluate the micromorphometry of hair follicles. Results showed that both male and female serum dihydrotestosterone levels were significantly reduced (60-70%) by finasteride treatment. Both males and females showed statistically significant increases in mean hair weight over the treatment period compared to controls (P = 0.034). In addition, there was a statistically significant increase in mean follicle length (measured histologically in scalp biopsies) compared to baseline in the finasteride-treated animals (P = 0.028). These data show that an inhibition of 5 alpha-reductase in the stumptail macaque can reverse the balding seen with age in both the male and female animals.