Sessile hemocytes as a hematopoietic compartment in Drosophila melanogaster
Sessile hemocytes as a hematopoietic compartment in Drosophila melanogaster
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DOI：
10.1073/pnas.0801766106
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发表时间：
2009-03-24
影响因子：
11.1
通讯作者：
Ando, Istvan
中科院分区：
文献类型：
--
作者：
Markus, Robert;Laurinyecz, Barbara;Ando, Istvan
果蝇中的血细胞或血细胞通过产生抗菌肽、吞噬细菌以及封装较大的异物颗粒（例如寄生卵）来参与免疫反应。这些免疫反应是由系统发育上保守的机制介导的。包封反应类似于脊椎动物肉芽肿的形成，并且由大型特化细胞（层状细胞）介导。层状细胞的起源尚未正式确定，尽管有人认为它们源自淋巴腺，而淋巴腺通常被认为是果蝇幼虫的主要造血器官。然而，最近观察到，表皮下的无蒂血细胞群被释放到循环系统中以响应寄生蜂感染。我们着手系统地分析这一现象。因此，我们将无蒂血细胞定义为一种新型的
The blood cells, or hemocytes, in Drosophila participate in the immune response through the production of antimicrobial peptides, the phagocytosis of bacteria, and the encapsulation of larger foreign particles such as parasitic eggs; these immune reactions are mediated by phylogenetically conserved mechanisms. The encapsulation reaction is analogous to the formation of granuloma in vertebrates, and is mediated by large specialized cells, the lamellocytes. The origin of the lamellocytes has not been formally established, although it has been suggested that they are derived from the lymph gland, which is generally considered to be the main hematopoietic organ in the Drosophila larva. However, it was recently observed that a subepidermal population of sessile blood cells is released into the circulation in response to a parasitoid wasp infection. We set out to analyze this phenomenon systematically. As a result, we define the sessile hemocytes as a novel