Stevens‐Johnson syndrome and toxic epidermal necrolysis cases treated at our hospital over the past 10 years.
Stevens‐Johnson syndrome and toxic epidermal necrolysis cases treated at our hospital over the past 10 years.
复制标题
我院近10年来收治的Stevens-Johnson综合征及中毒性表皮坏死松解症病例。
DOI：
10.1002/cia2.12044
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Katoh N.
中科院分区：
文献类型：
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作者：
Nakae M;Tamagawa-Mineoka R;Masuda K;Ueta M;Sotozono C;Katoh N.
史蒂文斯-约翰逊综合征（SJS）和中毒性表皮坏死松解症（TEN）是皮肤和粘膜（例如眼表）的急性炎症性疾病。本研究旨在评估我院SJS/TEN患者的背景、临床症状和病程。我们回顾性收集了2007年4月至2017年3月期间在京都府立医科大学医院皮肤科诊断的SJS或TEN患者的病史、临床症状、检查和治疗数据。研究对象为15例SJS患者和5例TEN患者。五个孩子均出现感冒症状，并服用感冒药。另一方面，15名成年患者服用了各种药物，如抗生素、感冒药或抗惊厥药。有趣的是，所有儿童患者都没有大的皮肤病变，但有严重的眼部症状，而成年患者皮肤和粘膜病变的严重程度各不相同。所有患者均接受口服皮质类固醇治疗。此外，18 名患者接受了皮质类固醇冲击治疗，6 名患者接受了大剂量免疫球蛋白治疗，1 名患者接受了血浆置换治疗。我们的研究结果表明，感冒症状和感冒药物可能与 SJS/TEN 患者的严重眼部受累有关。
Stevens‐Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute inflammatory diseases of the skin and mucous membranes such as the ocular surface. This study aimed to evaluate the backgrounds, clinical symptoms, and disease course of SJS/TEN patients in our hospital. We retrospectively collected the data of the medical history, clinical symptoms, examinations, and treatments in patients with SJS or TEN, which were diagnosed in the Department of Dermatology, Kyoto Prefectural University of Medicine Hospital between April 2007 and March 2017. The subjects were 15 patients with SJS and five with TEN. All five children had cold symptoms and took cold medications. On the other hand, 15 adult patients took various types of drugs, such as antibiotics, cold medications, or anticonvulsants. Interestingly, all pediatric patients did not have large skin lesions but suffered from severe eye symptoms, while the severity of their skin and mucous lesions was various in adult patients. All patients were treated with oral corticosteroid therapy. Furthermore, 18 patients were treated with corticosteroid pulse therapy, six with high‐dose immunoglobulin therapy, and one with plasmapheresis. Our findings imply that cold symptoms and cold medicines may be associated with severe ocular involvement in SJS/TEN patients.