Bone mass preservation with high-dose cholecalciferol and dietary calcium in HIV patients following antiretroviral therapy. Is it possible?
Bone mass preservation with high-dose cholecalciferol and dietary calcium in HIV patients following antiretroviral therapy. Is it possible?
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DOI：
10.1080/15284336.2018.1525841
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发表时间：
2018-01-01
影响因子：
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通讯作者：
Chessa, Luchino
中科院分区：
文献类型：
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作者：
Mela, Quirico;Ruggiero, Valeria;Chessa, Luchino
目的：评价不同CART方案下HIV患者每月给予10万IU胆钙化醇(相当于3200 IU/d)和1g/d膳食补钙治疗后，维生素D3和甲状旁腺素(PTH)水平是否正常，以及骨密度变化是否具有临床意义。参与者在基线(T0)和24个月后(T1)通过脊柱和髋部的双能X射线骨密度测量进行骨密度评估。在T0和T1时测定25(OH)维生素D3和甲状旁腺激素(PTH)水平。定量变量使用配对t检验、独立t检验或方差分析进行评估。使用卡方分析来评估定性变量之间的关联。一个p值
Objective: To evaluate whether treatment with 100,000 IU/month (equivalent to 3200 IU/day) of cholecalciferol and 1g/day of dietary calcium supplementation in HIV patients following different cART regimens yields normal levels of vitamin D3 and PTH as well as whether changes in bone mineral density are clinically significant.Methods: Consecutive HIV patients following different cART regimens received 100,000 IU/month (equivalent to 3200 IU/day) of cholecalciferol and 1 g/day of dietary calcium supplementation. The participants underwent BMD assessment via dual energy X-ray absorptiometry of the spine and hip at baseline (T0) and after 24 months (T1). Levels of 25(OH) vitamin D3 and parathyroid hormone (PTH) were assessed at T0 and T1. Quantitative variables were assessed with a paired t-test, independent t-test or analysis of variance, as appropriate. A chi-squared analysis was used to assess the association between qualitative variables. A p-value