Stress-induced modulation of vagal afferents.
Stress-induced modulation of vagal afferents.
复制标题
压力诱导的迷走神经传入调节。
DOI：
10.1111/nmo.13758
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Browning,KirsteenN
中科院分区：
文献类型：
--
作者：
Browning,KirsteenN
迷走神经依赖的胃功能，包括运动性、张力、顺应性和排空率，在食物摄入和饱足的调节中起重要作用。迷走神经传入纤维集中传递来自胃的感觉信息，包括与食物相关的信息，并启动协调的自主传出反应，调节上消化道反应。这篇综述的目的是强调最近的几项研究，这些研究揭示了胃机械敏感性迷走神经传入神经的显著程度的神经可塑性，以及Li等人最近在本期《神经胃肠病学与运动》杂志上的研究，他们表明胃迷走神经传入神经的机械敏感性在慢性应激小鼠模型中失调。研究表明，慢性应激后，胃粘膜和张力传入神经都是超敏的，对粘膜抚摸和肌肉拉伸的反应明显增强。由于胃膨胀和胃容量信号在饱腹感信号和用餐终止中很重要，这可能为胃超敏反应与应激相关的临床问题（如功能性消化不良）相关提供了机制基础。
Vagally dependent gastric functions, including motility, tone, compliance, and emptying rate, play an important role in the regulation of food intake and satiation. Vagal afferent fibers relay sensory information from the stomach, including meal‐related information, centrally and initiate co‐ordinated autonomic efferent responses that regulate upper gastrointestinal responses. The purpose of this mini‐review is to highlight several recent studies which have uncovered the remarkable degree of neuroplasticity within gastric mechanosensitive vagal afferents and the recent study by Li et al, in this issue ofNeurogastroenterology and Motility,who show that the mechanosensitivity of gastric vagal afferents is dysregulated in a murine model of chronic stress. The authors demonstrate that both gastric mucosal and tension afferents are hypersensitive following chronic stress, and responses to mucosal stroking and muscle stretch are enhanced significantly. As gastric distension and volumetric signaling is important in satiety signaling and meal termination, this may provide a mechanistic basis for the gastric hypersensitivity associated with stress‐associated clinical problems such as functional dyspepsia.