Early-pregnancy maternal vitamin D status and maternal hyperglycaemia.
Early-pregnancy maternal vitamin D status and maternal hyperglycaemia.
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妊娠早期母亲维生素 D 状况和母亲高血糖。
DOI：
10.1111/dme.12229
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
Bodnar,LM
中科院分区：
文献类型：
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作者：
Tomedi,LE;Simhan,HN;Bodnar,LM
AimsTo estimate the association between serum 25‐hydroxyvitamin D concentrations and maternal hyperglycaemia (post‐load glucose concentration ≥ 7.5 mmol/l).MethodsPregnant women (n=429; 61% black, 36% obese, 45% smokers) enrolled in a cohort study at <16 weeks gestation. Non‐fasting blood samples were assayed for serum 25‐hydroxyvitamin D at enrolment. At 24–28 weeks gestation, maternal hyperglycaemia was determined using a 50‐g 1‐h oral glucose challenge test.ResultsA total of 67% of women had 25‐hydroxyvitamin D concentrations < 50 nmol/l and 11% had maternal hyperglycaemia. Among smokers, each 23‐nmol/l increase in serum 25‐hydroxyvitamin D was associated with a reduction in the odds of maternal hyperglycaemia [odds ratio: 0.30 (95% CI: 0.13, 0.68)] after adjustment for parity, race/ethnicity, age, pre‐pregnancy BMI, marital status, income, family history of diabetes, and gestational age of gestational diabetes mellitus screening. Among non‐smokers, we found no association between early pregnancy vitamin D status and maternal hyperglycaemia.ConclusionsSmoking status may modify the relationship between poor maternal vitamin D status and maternal hyperglycaemia.
