White matter changes with age utilizing quantitative diffusion MRI
White matter changes with age utilizing quantitative diffusion MRI
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DOI：
10.1212/wnl.0000000000000597
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发表时间：
2014-07-15
期刊：
影响因子：
9.9
通讯作者：
Paul, Robert H.
中科院分区：
文献类型：
--
作者：
Baker, Laurie M.;Laidlaw, David H.;Paul, Robert H.
目的：应用定量扩散磁共振成像（MRI）技术，探讨年龄与脑特定白质束平均白质纤维束长度的关系。方法：63例50岁以上健康成人行弥散张量成像。脑白质纤维束的束束造影示图来源于弥散张量成像数据。结果：结果显示，在50岁以上，前丘脑辐射每增加1年，FBLs明显缩短。结论：我们利用量化扩散MRI研究了年龄对健康老年人大脑特定白质束FBL的影响。结果显示年龄与FBL呈显著负相关。需要对整个生命周期的FBL进行纵向研究，以检查白质完整性的具体变化。
Objective: To investigate the relationship between older age and mean cerebral white matter fiber bundle lengths (FBLs) in specific white matter tracts in the brain using quantified diffusion MRI.Methods: Sixty-three healthy adults older than 50 years underwent diffusion tensor imaging. Tractography tracings of cerebral white matter fiber bundles were derived from the diffusion tensor imaging data.Results: Results revealed significantly shorter FBLs in the anterior thalamic radiation for every 1-year increase over the age of 50 years.Conclusions: We investigated the effects of age on FBL in specific white matter tracts in the brains of healthy older individuals utilizing quantified diffusion MRI. The results revealed a significant inverse relationship between age and FBL. Longitudinal studies of FBL across a lifespan are needed to examine the specific changes to the integrity of white matter.