Synthesis of polycyclic scaffolds via a gold-catalysed dearomative cyclisation cascade
Synthesis of polycyclic scaffolds via a gold-catalysed dearomative cyclisation cascade
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DOI：
10.1016/j.tet.2020.131392
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发表时间：
2020-08-28
期刊：
影响因子：
2.1
通讯作者：
Unsworth, William P.
中科院分区：
文献类型：
--
作者：
Clarke, Aimee K.;Rossi-Ashton, James A.;Unsworth, William P.
在阿库阿米林生物碱天然产物中发现的多环支架可以通过金（I）催化的脱芳环化级联序列从炔醚化吲哚合成。ynone的起始原料本身是通过简单的色胺和乙醇衍生物的两步模块化合成制成的。(C)2020爱思唯尔有限公司保留所有权利。
Polycyclic scaffolds found in akuammiline alkaloid natural products can be synthesised from ynonetethered indoles, via a gold(I)-catalysed dearomative cyclisation cascade sequence. The ynone starting materials are themselves made via a two-step modular synthesis from simple tryptamine and tryptophol derivatives. (C) 2020 Elsevier Ltd. All rights reserved.