Serum diacron-reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) in patients with ATTR-PN.
Serum diacron-reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) in patients with ATTR-PN.
复制标题
ATTR-PN 患者的血清涤纶活性氧代谢物 (d-ROM) 和生物抗氧化潜力 (BAP)。
DOI：
10.1080/13506129.2019.1583183
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发表时间：
2019
期刊：
影响因子：
5.5
通讯作者：
Ueda M.
中科院分区：
文献类型：
--
作者：
Obayashi K;Masuda T;Tasaki M;Ando Y;Ueda M.
尽管越来越多的证据表明氧化应激参与神经系统疾病[文献1]，但atr - pn引起的神经病变中氧介导损伤的证据仍有待讨论。近年来，一种同时测定血液中diacon -reactive oxygen metabolites （d-ROMs）和biological oxidative potential （BAP）的方法被开发出来。在本研究中，我们计算了attrn - pn患者和无症状ATTRm携带者的d- rom /BAP比率，并评估其作为这些受试者神经病变评估指标的潜力。
BackgroundAlthough there is growing evidence suggesting the involvement of oxidative stress in neurological disorders [Citation 1], evidence of oxygen-mediated damage in neuropathy due to ATTR-PN remains to be discussed. Recently, a method of measuring both diacron-reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) in blood has been developed. In this study, we calculated d-ROMs/BAP ratio in ATTR-PN patients and asymptomatic ATTRm carriers, and assessed its potential as an evaluating marker of neuropathy in these subjects.