Testosterone Levels in Umbilical-Cord Blood and Risk of Pyloric Stenosis
Testosterone Levels in Umbilical-Cord Blood and Risk of Pyloric Stenosis
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DOI：
10.1542/peds.2010-2127
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发表时间：
2011-01-01
期刊：
影响因子：
8
通讯作者：
Fischer, Thea K.
中科院分区：
文献类型：
--
作者：
Krogh, Camilla;Cohen, Arieh S.;Fischer, Thea K.
目的：婴儿肥厚性幽门狭窄的风险在男婴中是女婴的5倍。据推测，男婴中较高的风险与高水平的睾酮导致幽门肌肉肥大有关。为了验证这一假设，我们研究了睾丸激素水平在脐带血和婴儿肥厚性幽门stenosis.PATIENTS和方法的风险之间的关联：我们进行了匹配的病例对照研究嵌套在丹麦国家出生队列使用风险集抽样。从101042例孕妇队列中，我们确定了46例病例受试者（43名男性和3名女性婴儿）的脐带血样本，这些病例在出生后第一年发生婴儿肥厚性幽门狭窄，并确定了150例性别和胎龄匹配的对照受试者。采用液相色谱-串联质谱法测定睾酮水平。结果：在男婴中，出生时的平均睾酮水平为0.78 nmol/L的病例组和0.91 nmol/L的对照组。婴儿肥厚性幽门狭窄的发生率与男婴的睾酮水平呈负相关，但不显著;每nmol/L的发生率低29%（95%置信区间：-46%至65%; P = 35）。根据年龄，胎龄，或birth orders.CONCLUSIONS：我们发现没有支持的假设，即高睾酮水平的脐带血中的男性婴儿的婴儿肥厚性幽门狭窄的风险较高，随后密切相关。儿科2011;127：e197-e201
OBJECTIVE: The risk of infantile hypertrophk pylonc stenosis is similar to 5 times more common in male than female infants. It has been hypothesized that the higher risk among male infants is associated with high levels of testosterone causing hypertrophy of the pylorus muscle. To test this hypothesis, we examined the association between the testosterone levels in the umbilical-cord blood and the risk of infantile hypertrophic pyloric stenosis.PATIENTS AND METHODS: We conducted a matched case-control study nested in the Danish National Birth Cohort using risk-set sampling. From a cohort of 101 042 pregnancies, we identified umbilical-cord blood samples from 46 case subjects (43 male and 3 female infants) who developed infantile hypertrophic pyloric stenosis in the first year of life and 150 gender-and gestational age-matched control subjects. The testosterone levels were measured by liquid chromatography-tandem mass spectrometry. Rate ratios were estimated by using conditional logistic regression.RESULTS: In male infants, the mean testosterone level at birth was 0.78 nmol/L in case subjects and 0.91 nmol/L in control subjects. The rate of infantile hypertrophic pyloric stenosis was inversely, albeit insignificantly, associated with the testosterone levels in male infants; there was a 29% (95% confidence interval: -46% to 65%; P = 35) lower rate per nmol/L. The association was not modified according to age, gestational age, or birth order.CONCLUSIONS: We found no support for the hypothesis that high testosterone levels in the umbilical-cord blood are strongly associated with a subsequently higher risk for infantile hypertrophic pyloric stenosis in male infants. Pediatrics 2011;127:e197-e201