Effects of testosterone on Reelin expression in the brain of male European starlings
Effects of testosterone on Reelin expression in the brain of male European starlings
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DOI：
10.1007/s00441-003-0701-9
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发表时间：
2003-04-01
影响因子：
3.6
通讯作者：
Eens, M
中科院分区：
文献类型：
--
作者：
Absil, P;Pinxten, R;Eens, M
Reelin是一种在reeler小鼠中有缺陷的大糖蛋白，被认为决定了发育中大脑中迁移神经元的最终位置。我们研究了成年雄性欧洲欧椋鸟大脑中Reelin的表达，这些欧椋鸟接受了外源性睾酮治疗或未接受外源性睾酮治疗。Reelin免疫反应阳性细胞和纤维广泛分布于前脑，包括鸣唱控制核（HVC）内和周围区域。没有标记，检测到其他歌曲控制核，除了核uvaeformis，这是划定了一个密集的集群的Reelin免疫反应的胞体。因此，Reelin在成年时在包含新神经元的区域中表达，例如HVC。在HVC，葡萄膜状核和背侧丘脑，但不是在其他脑区的Reelin表达急剧下降睾酮。这些结果与Reelin表达的季节性变化调节HVC内神经元的掺入的想法一致。然而，Reelin在成年期不包含新神经元的其他大脑区域中的存在表明，这种蛋白质必须在成人大脑中发挥其他无关的作用。现在应该进行更多的研究，以确定这种蛋白质在鸣禽大脑的季节性可塑性中所起的具体作用。
Reelin, a large glycoprotein defective in reeler mice, is assumed to determine the final location of migrating neurons in the developing brain. We studied the expression of Reelin in the brain of adult male European starlings that had been treated or not with exogenous testosterone. Reelin-immunoreactive cells and fibers were widely distributed in the forebrain including areas in and around the song control nucleus, HVC. No labeling was detected in other song control nuclei with the exception of nucleus uvaeformis, which was delineated by a dense cluster of Reelin-immunoreactive perikarya. Reelin is thus expressed in areas incorporating new neurons in adulthood, such as HVC. Reelin expression was sharply decreased by testosterone in HVC, nucleus uvaeformis and dorsal thalamus but not in other brain regions. These results are consistent with the idea that seasonal changes in Reelin expression modulate the incorporation of neurons within HVC. The presence of Reelin in other brain areas that do not incorporate new neurons in adulthood indicates, however, that this protein must play other unrelated roles in the adult brain. Additional studies should now be carried out to determine the specific role played by this protein in the seasonal plasticity of the songbird brain.