Gender difference in association between polymorphism of serotonin transporter gene regulatory region and anxiety
Gender difference in association between polymorphism of serotonin transporter gene regulatory region and anxiety
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DOI：
10.1016/j.jpsychores.2005.06.068
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发表时间：
2006-01-01
影响因子：
4.7
通讯作者：
Fukudo, S
中科院分区：
文献类型：
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作者：
Mizuno, T;Aoki, M;Fukudo, S
目的：本研究旨在验证5-羟色胺转运体基因启动子区（5-HTTLPR）变异与应激敏感性相关的假设。方法：对194名受试者进行5-HTTLPR基因分型和情绪状态评估。受试者的情绪状态采用感知压力量表（PSS）、状态-特质焦虑量表（STAI）和抑郁自评量表（SDS）进行评估。结果：STAI存在性别×基因型交互作用（状态，P
Objective: The objective of this study was to verify the hypothesis that variation of the serotonin transporter gene promoter region (5-HTTLPR) is associated with sensitivity to stress. Methods: Genotyping of 5-HTTLPR and evaluation of emotional states were performed on 194 participants. Participants' emotional states were evaluated using the Perceived-Stress Scale (PSS), the State-Trait Anxiety Inventory (STAI), and the Self-rating Depression Scale (SDS). Results: There was significant Gender x Genotype interaction in STAI (state, P