From KISS1 to kisspeptins: An historical perspective and suggested nomenclature.

From KISS1 to kisspeptins: An historical perspective and suggested nomenclature.
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从 KISS1 到 Kisspeptins:历史视角和建议命名法。

DOI:
10.1016/j.peptides.2008.06.016
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发表时间:
2009-01
期刊:
影响因子:
3
通讯作者:
Steiner, Robert A.
Steiner, Robert A.
中科院分区:
医学3区
文献类型:
--
作者:
Gottsch, Michelle L.;Clifton, Donald K.;Steiner, Robert A.

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癌症抑制基因KISS 1最初被描述为在抑制癌症转移中具有重要作用。从那时起,KISS 1及其受体KISS 1 R已被证明在控制人类和其他物种的生殖生理青春期的开始方面发挥关键作用。最近的研究还将KISS 1/KISS 1 R/kisspeptin与其他过程联系起来,如血管收缩,衰老,脂肪细胞生理学,以及可能作为连接代谢和生殖的分子管道。本文重点介绍了KISS 1/KISS 1 R/kisspeptin生物学的历史,并提出了这一信号通路中关键分子的命名共识。
The cancer suppressor gene, KISS1, was initially described as having an important role in inhibiting cancer metastasis. Since then, KISS1 and its receptor, KISS1R, have been shown to play a key role in controlling the onset of puberty of reproductive physiology in the human and other species. Recent studies have also linked KISS1/KISS1R/kisspeptin to other processes, such as vasoconstriction, aging, adipocyte physiology, and perhaps as a molecular conduit linking metabolism and reproduction. This article highlights the history of KISS1/KISS1R/kisspeptin biology and proposes a consensus for nomenclature of the key molecules in this signaling pathway.
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