Defective mucosal movement at the gastroesophageal junction in patients with gastroesophageal reflux disease.
Defective mucosal movement at the gastroesophageal junction in patients with gastroesophageal reflux disease.
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DOI：
10.1007/s10620-014-3091-9
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发表时间：
2014-08
影响因子：
3.1
通讯作者：
Miller LS
中科院分区：
文献类型：
--
作者：
Vegesna AK;Patel H;Weissman S;Patel A;Kissel M;Indukuri S;Nimma A;Dai Q;Miller LS
粘膜肌层在胃食道交界处(GEJ)的作用知之甚少。目的：探讨正常人和胃食道反流病(GERD)患者胃小关节粘膜/肌层-粘膜/粘膜下层(MMS)的运动规律。用两种方法对20例非GERD患者和10例GERD患者的胃-食道连接部进行了5ml吞咽试验：1)高分辨率腔内超声和测压--测量管腔压力和食管壁横截面积的变化。2)腹部超声--分析中膜在GEJ处的运动情况。在非GERD受试者中，胃MMS在推进剂第一次到达GEJ后2.17秒从吻部移动到食道远端。在GERD患者中，胃MMS没有沿吻部移动到远端食道。非GERD组和GERD组胃食道MMS横截面积最大变化值分别为289%和183%。在非GERD受试者中，胃MMS在吞咽开始后(1.75秒比3.00秒)和(13.97毫米比8.91毫米)比固有肌(MP)更早和更远地开始向吻侧移动。在GERD患者中，与MP相比，胃MMS的运动无显著差异(6.74 mm比6.09 mm)。GERD患者胃MMS自主运动明显低于非GERD患者。在非GERD受试者中，胃MMS在吞咽抑制期间沿嘴部移动到远端食道，并形成屏障。在GERD患者中，MMS的这种运动是有缺陷的。
Little is known about the role of muscularis mucosa at gastroesophageal junction (GEJ). To evaluate the movement of the mucosa/ muscularis-mucosa/submucosa (MMS) at the GEJ in normal subjects and in patients with gastroesophageal reflux disease (GERD). Gastroesophageal junctions of 20 non-GERD subjects and 10 patients with GERD were evaluated during 5mL swallows using two methods: 1) High-resolution endoluminal ultrasound and manometry-the change in the GEJ luminal pressures and cross-sectional area of esophageal wall layers were measured. 2) Abdominal ultrasound-the MMS movement at the GEJ was analyzed. In the non-GERD subjects, the gastric MMS moved rostrally into the distal esophagus at 2.17 sec after the bolus first reached the GEJ. In GERD patients the gastric MMS did not move rostrally into the distal esophagus. The maximum change in cross-sectional area of gastroesophageal MMS in non-GERD subjects and in GERD patients were 289% and 183% respectively. In non-GERD subjects the gastric MMS starts to move rostrally significantly earlier and to a greater distance than muscularis propria (MP) after the initiation of the swallow (1.75sec vs. 3.00sec) and (13.97mm vs. 8.91mm). In GERD patients, there is no significant difference in the movement of gastric MMS compared to MP (6.74mm vs. 6.09mm). The independent movement of the gastric MMS in GERD subjects was significantly less than in non-GERD subjects. In non-GERD subjects the gastric MMS moves rostrally into the distal esophagus during deglutitive inhibition and forms a barrier. This movement of the MMS is defective in patients with GERD.
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影响因子：
29.4
作者：
KAHRILAS, PJ;WU, S;POUDEROUX, P
通讯作者：
POUDEROUX, P
DOI：
10.1152/ajpgi.00235.2004
发表时间：
2005-07-01
影响因子：
4.5
作者：
Ghosh, SK;Kahrilas, PJ;Brasseur, JG
通讯作者：
Brasseur, JG
影响因子：
29.4
作者：
Pouderoux, P;Lin, SZ;Kahrilas, PJ
通讯作者：
Kahrilas, PJ
影响因子：
3.2
作者：
Meneghetti, A;Tedesco, P;Patti, MG
通讯作者：
Patti, MG
影响因子：
15.9
作者：
DODDS, WJ;STEWART, ET;ZBORALSKE, FF
通讯作者：
ZBORALSKE, FF