Quantitative assessment of the association between AXIN2 rs2240308 polymorphism and cancer risk.
Quantitative assessment of the association between AXIN2 rs2240308 polymorphism and cancer risk.
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AXIN2 rs2240308 多态性与癌症风险之间关联的定量评估
DOI：
10.1038/srep10111
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发表时间：
2015-05-14
影响因子：
4.6
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Gong J;Jiang Y;Hao N;Zhu B;Li Y
Axin 2参与Wnt/β-catenin通路的调控，参与肿瘤的发生和发展。AXIN 2 rs 2240308多态性与癌症风险之间的关联已在几项病例对照研究中进行了研究，但结论相互矛盾。在这里，我们进行了一项荟萃分析，以评估rs 2240308在癌症风险中的作用。本荟萃分析共纳入8项研究（1559例癌症病例和1503例对照）。评估合并比值比（OR）和95%置信区间（CI），以评估AXIN 2 rs 2240308多态性与癌症易感性的相关性。纯合子（TTvs.CC）、杂合子（CTvs. CC）、显性（CT+TTvs.CC）和等位基因（Tvs. C）模型中观察到总体癌症风险显着降低（P< 0.005），而不是隐性（TTvs.CT+CC）模型（P= 0.092）。AXIN 2多态性rs 2240308也与肺癌的所有五种模型下的癌症风险降低相关。然而，AXIN 2 rs 2240308多态性与土耳其人群中的任何上述模型以及日本人群中的纯合、杂合、隐性模型下的癌症风险无关。这些发现表明AXIN 2 rs 2240308多态性与癌症风险降低显著相关，并且具有种族特异性。
Axin2 is involved in the regulation of Wnt/β-catenin pathway and implicated in cancer development and progression. The association betweenAXIN2rs2240308 polymorphism and cancer risk has been examined in several case-control studies, but the conclusions were conflicting. Here we performed a meta-analysis to evaluate the role of rs2240308 in cancer risk. A total of 8 studies were included in this meta-analysis (1559 cancer cases and 1503 controls). The pooled odds ratios (OR) and the 95% confidence intervals (CIs) were assessed to evaluate the association of theAXIN2rs2240308 polymorphism with a susceptibility to cancer. A significantly decreased overall cancer risk was observed in the homozygous (TTvs.CC), heterozygous (CTvs.CC), dominant (CT+TTvs.CC) and allelic (Tvs.C) models (P< 0.005), rather than that in the recessive (TTvs.CT+CC) model (P= 0.092). AXIN2polymorphism rs2240308 was also associated with decreased cancer risk under all five models in lung cancer. However,AXIN2rs2240308 polymorphism was not associated with cancer risk under any above model in Turkish population and under homozygous, heterozygous, recessive models in Japanese population. These findings indicate thatAXIN2rs2240308 polymorphism significantly and race-specifically correlates with decreased cancer risk.
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影响因子：
56.9
作者：
Behrens, J;Jerchow, BA;Birchmeier, W
通讯作者：
Birchmeier, W
DOI：
10.1158/1055-9965.epi-08-0134
发表时间：
2008-08
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Wang X;Goode EL;Fredericksen ZS;Vierkant RA;Pankratz VS;Liu-Mares W;Rider DN;Vachon CM;Cerhan JR;Olson JE;Couch FJ
通讯作者：
Couch FJ
影响因子：
2.8
作者：
Naghibalhossaini, Fakhraddin;Zamani, Mozhdeh;Mostafavi-pour, Zohreh
通讯作者：
Mostafavi-pour, Zohreh
影响因子：
4
作者：
Mostowska A;Pawlik P;Sajdak S;Markowska J;Pawałowska M;Lianeri M;Jagodzinski PP
通讯作者：
Jagodzinski PP
DOI：
10.1159/000056942
发表时间：
2001-01-01
期刊：
CYTOGENETICS AND CELL GENETICS
影响因子：
--
作者：
Dong, X;Seelan, RS;Liu, W
通讯作者：
Liu, W