Effects of brief stress exposure during early postnatal development in balb/CByJ mice: I. Behavioral characterization
Effects of brief stress exposure during early postnatal development in balb/CByJ mice: I. Behavioral characterization
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DOI：
10.1002/dev.21027
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发表时间：
2013-04-01
影响因子：
2.2
通讯作者：
Aneni, Justin
中科院分区：
文献类型：
--
作者：
Hohmann, Christine F.;Hodges, Amber;Aneni, Justin
早期生活压力与心理健康障碍的病因有关。新生儿母亲分离应激的啮齿动物模型经常被用来探索早期应激对情感和认知行为变化的长期影响。然而，大多数目前的范例的风险代谢剥夺，由于长期的幼犬从大坝。我们在Balb/CByJ小鼠中开发了一种新的范例，将非常短暂的母体分离与温度应激相结合，以避免营养缺乏的混淆。我们还纳入了未从母鼠中取出的幼仔的窝内对照组。目前的实验提供了一个初步的行为表征这种新的模式。我们发现，应激小鼠表现出焦虑和攻击性增加，沿着运动增加，但探索行为减少。与此相反，同窝对照组显示出增加的探索新奇，相比，年龄匹配，殖民地饲养的控制。我们短暂应激小鼠的行为变化与现有文献基本一致，除了我们无法观察到任何认知缺陷。然而，我们发现，在窝控制幼崽也持续的行为变化，这表明复杂和持久的相互作用，不同的环境因素在出生后的早期生活。(c)2012 Wiley Periodicals，Inc. Dev Psychobiol 55：283293，2013
Early life stress has been linked to the etiology of mental health disorders. Rodent models of neonatal maternal separation stress frequently have been used to explore the long-term effects of early stress on changes in affective and cognitive behaviors. However, most current paradigms risk metabolic deprivation, due to prolonged periods of pup removal from the dam. We have developed a new paradigm in Balb/CByJ mice, that combines very brief periods of maternal separation with temperature stress to avoid the confound of nutritional deficiencies. We have also included a within-litter control group of pups that are not removed from the dam. The present experiments provide an initial behavioral characterization of this new model. We show that neonatally stressed mice display increased anxiety and aggression along with increased locomotion but decreased exploratory behavior. In contrast, littermate controls show increased exploration of novelty, compared to age-matched, colony-reared controls. Behavioral changes in our briefly stressed mice substantially concur with the existing literature, except that we were unable to observe any cognitive deficits in our paradigm. However, we show that within litter control pups also sustain behavioral changes suggesting complex and long-lasting interactions between different environmental factors in early postnatal life. (c) 2012 Wiley Periodicals, Inc. Dev Psychobiol 55: 283293, 2013