Malaria Molecular Epidemiology: Lessons from the International Centers of Excellence for Malaria Research Network.
Malaria Molecular Epidemiology: Lessons from the International Centers of Excellence for Malaria Research Network.
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DOI：
10.4269/ajtmh.15-0005
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发表时间：
2015-09
期刊：
影响因子：
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通讯作者：
Felger I
中科院分区：
文献类型：
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作者：
Escalante AA;Ferreira MU;Vinetz JM;Volkman SK;Cui L;Gamboa D;Krogstad DJ;Barry AE;Carlton JM;van Eijk AM;Pradhan K;Mueller I;Greenhouse B;Pacheco MA;Vallejo AF;Herrera S;Felger I
分子流行病学利用遗传信息来研究影响疟疾病例发生频率和分布的危险因素。本文描述了目前由国际疟疾研究卓越中心（ICEMR）网络在各种疟疾流行环境中开展的分子流行病学调查。首先，我们讨论了了解疟疾发病率和配子体的各种新方法，重点是恶性疟原虫和间日疟原虫。其次，我们描述和比较了疟疾流行病学和群体遗传学中常用的不同寄生虫基因分型方法。最后，我们讨论了分子流行病学工具和方法在疟疾控制和消除工作中的潜在应用。
Molecular epidemiology leverages genetic information to study the risk factors that affect the frequency and distribution of malaria cases. This article describes molecular epidemiologic investigations currently being carried out by the International Centers of Excellence for Malaria Research (ICEMR) network in a variety of malaria-endemic settings. First, we discuss various novel approaches to understand malaria incidence and gametocytemia, focusing on Plasmodium falciparum and Plasmodium vivax. Second, we describe and compare different parasite genotyping methods commonly used in malaria epidemiology and population genetics. Finally, we discuss potential applications of molecular epidemiological tools and methods toward malaria control and elimination efforts.