Surgical treatment for hypopharynx carcinoma: Feasibility, mortality, and results
Surgical treatment for hypopharynx carcinoma: Feasibility, mortality, and results
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DOI：
10.1067/mhn.2001.115060
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发表时间：
2001-05-01
影响因子：
3.4
通讯作者：
Jungehuelsing, M
中科院分区：
文献类型：
--
作者：
Eckel, HE;Staar, S;Jungehuelsing, M
本研究旨在评估下咽癌患者的治疗方式、术后死亡率、生存率和局部控制率，这些患者根据一项前瞻性方案接受治疗，该方案支持将手术作为该疾病的初始方法。本文回顾了228例未经治疗的下咽鳞状细胞癌患者的病历资料。观察指标使用Kaplan-Meier估计法计算（总生存期、疾病特异性生存期和局部控制）。在228例连续患者中，92例中18例（59.6%）适合初次手术治疗7.8%的患者有不可切除的淋巴结转移，16例（7.0%）有不可切除的原发肿瘤，13例（5.7%）拒绝手术，13例（5.7%）在初始诊断评估时出现远处转移。在接受手术的患者中，46人接受了保留喉手术，54人接受了全喉切除术，36人接受了全喉咽切除术。所有228例患者的5年总生存率为27.2%，136例手术治疗患者的5年总生存率为39.5%，46例保留喉手术患者的5年总生存率为61.1%。
This study seeks to evaluate treatment modalities, mortality after surgery survival, and local control rates for a consecutive cohort of patients with cancer of the hypopharynx treated according to a prospective protocol that favors surgery as an initial approach to the disease. The charts of 228 consecutive patients with previously untreated hypopharyngeal squamous cell carcinoma were reviewed. Outcome measures (overall survival, disease specific survival, and local control) were calculated using the Kaplan-Meier estimator, Of 228 consecutive patients, 136 (59.6%) were found suitable for initial surgical treatment, Of the remaining 92 patients, 18 (7.8%) had nonresectable lymph node metastases, 16 (7.0%) had unresectable primary tumors, 13 (5.7%) refused surgery, and 13 (5.7%) presented distant metastases during initial diagnostic evaluation. Of those who had surgery, 46 had larynx-sparing procedures, 54 had total laryngectomy, and 36 had total laryngo-pharyngectomy. None of the patients who had surgery died postoperatively, Actuarial 5-year overall survival was 27.2% for all 228 patients, 39.5% for the 136 patients with surgical treatment, and 61.1% for the 46 patients who were treated with larynx-sparing procedures,