Lateral prefrontal anodal transcranial direct current stimulation augments resolution of auditory perceptual-attentional conflicts
Lateral prefrontal anodal transcranial direct current stimulation augments resolution of auditory perceptual-attentional conflicts
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DOI：
10.1016/j.neuroimage.2019.05.009
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发表时间：
2019-10-01
期刊：
影响因子：
5.7
通讯作者：
Li, Shu-Chen
中科院分区：
文献类型：
--
作者：
Adelhoefer, Nico;Gohil, Krutika;Li, Shu-Chen
成功的动作控制需要注意环境中相关感觉信号的能力。然而，当不同的感官输入争夺大脑有限的资源时，这可能会变得复杂。在这种情况下，感觉过程与自上而下的注意力相互作用，选择性地处理与目标相关的刺激，同时抑制无关或分散注意力的感觉信号。在目前的研究中，我们开始提供因果机制的见解是否以及如何前额叶区域参与解决注意知觉冲突。为此，我们应用atDCS和检查选择性听觉知觉的神经生理过程。为了评估是否atDCS差异影响混杂的神经生理子过程中涉及的冲突解决，我们分解的EEG数据使用残留迭代分解（RIDE）。我们发现，右前额叶区域的因果关系参与解决注意力知觉冲突和atDCS增加这样做的功效。数据显示，可分离的神经生理信号受到atDCS的特异性影响。冲突解决过程中，涉及抑制竞争刺激和反应评价，并与右额中回（BA46）似乎成为加强atDCS在解决注意力知觉冲突。刺激后的早期刺激处理水平也不太容易感觉冲突，但这本身不能解释与atDCS相关的行为效能增加。这些观察到的影响可能反映了神经元增益控制机制的变化。总之，这项研究的结果可能对治疗注意力多动障碍有影响，药物干预是目前常用的治疗方法。
Successful action control requires the ability to attend to relevant sensory signals in the environment. This, however, can be complicated when different sensory inputs compete for the brain's limited resources. Under such conditions, sensory processes interact with top-down attention to selectively process goal-relevant stimuli, while inhibiting irrelevant or distracting sensory signals. In the current study, we set out to provide causal mechanistic insights for whether and how prefrontal regions are involved in resolving attentional-perceptual conflicts. To this end, we applied atDCS and examined neurophysiological processes of selective auditory perception. To evaluate whether atDCS differentially affects intermingled neurophysiological subprocesses involved during conflict resolution, we decomposed the EEG data using residue iteration decomposition (RIDE). We show that the right prefrontal regions are causally involved in resolving attentional-perceptual conflicts and that atDCS increases the efficacy to do so. The data show that dissociable neurophysiological signals are specifically affected by atDCS. Conflict resolution processes that involve inhibition of competing stimuli and response evaluation and are associated with right middle frontal gyrus (BA46) seem to become intensified by atDCS during the resolution of attentional-perceptual conflicts. After stimulation the early stimulus processing level was also less prone to sensory conflicts, but this alone could not explain the increased behavioral efficacy associated with atDCS. These observed effects likely reflect changes in neuronal gain control mechanisms. Taken together, results of this study may have implications for treating attentional hyperactivity disorder, for which pharmacological intervention is currently the common therapeutic approach.