Concise synthesis of (S,S)-(+)-dehydrohomoancepsenolide.
Concise synthesis of (S,S)-(+)-dehydrohomoancepsenolide.
复制标题
(S,S)-( )-脱氢高头茅内酯的简明合成。
作者：
A. Fürstner;T. Dierkes
本文报道了一种简明的光学活性双丁烯酰亚胺3的全合成方法。关键步骤是锌介导的“三组分偶联”，形成二烯炔9，其在用（PCy（3））（2）Cl（2）Ru=CHPh处理时经历闭环复分解（RCM）。然后使用（tBuO）（3）Wbd 1;CCMe（3）作为催化剂通过炔复分解实现所得丁烯二醇11的二聚。Lindlar还原完成了该合成，其在仅五个步骤中以25%的总产率提供产物3。
A concise total synthesis of the bis-butenolide 3 in optically active form is reported. Key steps are a zinc-mediated "three-component coupling" with formation of dienyne 9 which undergoes ring closing metathesis (RCM) on treatment with (PCy(3))(2)Cl(2)Ru=CHPh. Dimerization of the resulting butenolide 11 is then achieved via alkyne metathesis using (tBuO)(3)W&tbd1;CCMe(3) as the catalyst. A Lindlar reduction completes this synthesis which delivers product 3 in only five steps with an overall yield of 25%.
来自加勒比八珊瑚 Pterogorgia citrina 的其他丁烯内酯。
影响因子：
5.1
作者：
Rodríguez,AD;Ramírez,C
通讯作者：
Ramírez,C