Stimuli-responsive polypeptides for controlled drug delivery
Stimuli-responsive polypeptides for controlled drug delivery
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用于受控药物递送的刺激响应性多肽
DOI：
10.1039/d1cc04053g
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发表时间：
2021
影响因子：
4.9
通讯作者：
Chen Xuesi
中科院分区：
文献类型：
--
作者：
Zhang Peng;Li Mingqian;Xiao Chunsheng;Chen Xuesi
受控的药物传递系统可以在所需的时间内根据生理触发因素在所需区域施加的物理化学变化释放负载的治疗药物，与传统的药物载体相比，具有许多优点，包括增强治疗效果和降低毒性。多肽是一种生物相容性和可生物降解的聚合物，通过引入具有先天刺激响应特性的天然氨基酸残基或使用简单的偶联方法在其侧链上引入响应部分，可以方便地赋予其刺激响应性，使其成为理想的生物医学材料。这篇专题文章总结了我们最近的工作和其他相关研究，以多肽为基础的药物传递系统，响应单一或多种生理刺激（如pH、氧化还原电位、葡萄糖和缺氧），以控制药物传递应用。阐述了这些刺激反应性多肽给药系统的材料设计、合成策略、药物的装载和控释机制以及生物医学应用。最后，简要讨论了该领域面临的挑战和机遇。
Controlled drug delivery systems, which could release loaded therapeutics upon physicochemical changes imposed by physiological triggers in the desired zone and during the required period of time, offer numerous advantages over traditional drug carriers including enhanced therapeutic effects and reduced toxicity. A polypeptide is a biocompatible and biodegradable polymer, which can be conveniently endowed with stimuli-responsiveness by introducing natural amino acid residues with innate stimuli-responsive characteristics or introducing responsive moieties to its side chains using simple conjugating methods, rendering it an ideal biomedical material for controlled drug delivery. This feature article summarizes our recent work and other relevant studies on the development of polypeptide-based drug delivery systems that respond to single or multiple physiological stimuli (e.g., pH, redox potential, glucose, and hypoxia) for controlled drug delivery applications. The material designs, synthetic strategies, loading and controlled-release mechanisms of drugs, and biomedical applications of these stimuli-responsive polypeptides-based drug delivery systems are elaborated. Finally, the challenges and opportunities in this field are briefly discussed.