CUTANEOUS MALIGNANT-MELANOMA IN ROCHESTER, MINNESOTA - TRENDS IN INCIDENCE AND SURVIVORSHIP, 1950 THROUGH 1985
CUTANEOUS MALIGNANT-MELANOMA IN ROCHESTER, MINNESOTA - TRENDS IN INCIDENCE AND SURVIVORSHIP, 1950 THROUGH 1985
复制标题
DOI：
10.1016/s0025-6196(12)62140-5
复制
发表时间：
1990-10-01
影响因子：
8.9
通讯作者：
KURLAND, LT
中科院分区：
文献类型：
--
作者：
POPESCU, NA;BEARD, CM;KURLAND, LT
在明尼苏达州的罗切斯特，1950年至1985年期间诊断出107例皮肤恶性黑色素瘤（46例男性和61例女性患者）。总体粗发病率分别为每100 000名男性和女性6.0和6.6人。对9年期间趋势的评估表明，男性的比率从3.2增加到8.9（P = 0.015），女性从4.4增加到11.7（P < 0.001）。特定年龄组的发病率表明，男性发病率最高的年龄组为50至59岁和70岁或以上，女性发病率最高的年龄组为40至49岁和70岁或以上。病变最常见于男性的头颈部（P = 0.044）和女性的下肢（P = 0.018）。最常见的组织学类型是浅表扩散性黑色素瘤（61%）。皮肤恶性肿瘤患者的五年生存率总体上降低melanoma.sbd.0.72而一般人群的预期生存率为0.88。统计学上显著的生存风险因素是病变浸润深度（Clark水平）、病变厚度、组织学类型和患者年龄。
In Rochester, Minnesota, 107 incidence cases of cutaneous malignant melanoma (in 46 male and 61 female patients) were diagnosed during the years 1950 through 1985. Overall crude incidence rates were 6.0 and 6.6 per 100,000 males and females, respectively. Evaluation of trends in 9-year periods showed that the rates increased from 3.2 to 8.9 for males (P = 0.015) and from 4.4 to 11.7 for females (P < 0.001). Age-specific rates suggested that the highest incidence occurs in the age-groups 50 to 59 years and 70 years or older for males and 40 to 49 years and 70 years or older for females. Lesions were most common in the head and neck area among males (P = 0.044) and on the lower extremities among females (P = 0.018). The most frequent histologic type was superficial spreading melanoma (61%). Five-year survival was diminished overall for patients with cutaneous malignant melanoma.sbd.0.72 in comparison with 0.88 expected for the general population. Statistically significant risk factors for survival were depth of invasion of the lesion (Clark level), thickness of the lesion, histologic type, and age of the patient.