Physical Activity and Cognitive Function in Middle-Aged and Older Adults: An Analysis of 104,909 People From 20 Countries
Physical Activity and Cognitive Function in Middle-Aged and Older Adults: An Analysis of 104,909 People From 20 Countries
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DOI：
10.1016/j.mayocp.2016.06.032
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发表时间：
2016-11-01
影响因子：
8.9
通讯作者：
Rolland, Yves
中科院分区：
文献类型：
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作者：
Barreto, Philipe de Souto;Delrieu, Julien;Rolland, Yves
目的：研究体力活动（PA）频率（中度和剧烈强度）和PA水平与认知功能的关系。患者和方法：从20个欧洲国家（沿着以色列）收集了50岁或以上的个人数据，从2004年到2013年11月，在欧洲健康，老龄化和退休的半年调查。共有104，909名参与者至少接受一次认知功能评估（平均随访时间为29.5 +/- 35.7个月）。参与者报告基线中度和重度PA每周超过一次，每周一次，每月一到三次，或者几乎没有或从未。关于PA频率，参与者被分类为不活跃、低活跃、中等活跃或高活跃。主要的结果测量是认知综合得分，通过对4项时间定向、延迟回忆的10个单词列表和语言流畅性的z得分进行求和来创建。调整后，2水平混合效应回归发现，与不做PA相比，每周做PA超过一次，每周一次，或一个月一到三次与综合评分呈正相关（中等强度PA的β系数为0.52 - 0.75，高强度PA的β系数为0.26 - 0.33）。同样，与不活动类别相比，高活动、中等活动和低活动类别与综合评分呈正相关（β值从0.77到1.10不等）。PA变量和认知tests.Conclusion的原始分数之间也获得了积极的关联：体力活动与认知功能的剂量反应协会，甚至低PA频率（每月几次）与认知功能在老化过程中正相关。(C)2016年马约医学教育和研究基金会
Objective: To examine the associations of physical activity (PA) frequency (both moderate and vigorous intensity) and PA levels with cognitive function.Patients and Methods: Data of individuals 50 years or older, from 20 European countries (along with Israel), were collected from 2004 to November 2013 in the biannual Survey of Health, Ageing and Retirement in Europe. A total of 104,909 participants were assessed for cognitive function at least once (mean follow-up length, 29.5 +/- 35.7 months). Baseline moderate- and vigorous-intensity PA were reported by participants as more than once a week, once a week, one to three times a month, or hardly ever or never. With regard to PA frequency, participants were categorized as inactive, low active, intermediate active, or high active. The main outcome measure is a cognitive composite score created by summing the z scores of 4-item temporal orientation, 10-word list for delayed recall, and verbal fluency.Results: Adjusted, 2-level mixed-effect regressions found that compared with doing no PA, doing PA more than once a week, once a week, or one to three times a month was positively associated with the composite score (beta coefficients varied from 0.52 to 0.75 for moderate-intensity PA and from 0.26 to 0.33 for vigorous-intensity PA). Similarly, compared with the inactive category, high-active, intermediate-active, and low-active categories had positive associations with the composite score (beta varied from 0.77 to 1.10). Positive associations were also obtained between PA variables and the raw scores of cognitive tests.Conclusion: Physical activity has dose-response associations with cognitive function, with even low PA frequencies (few times per month) being positively associated with cognitive function during aging. (C) 2016 Mayo Foundation for Medical Education and Research