The cooperative roles of Foxc1 and Foxc2 in cardiovascular development.
The cooperative roles of Foxc1 and Foxc2 in cardiovascular development.
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DOI：
10.1007/978-1-4419-1599-3_5
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发表时间：
2009
影响因子：
--
通讯作者：
T. Kume
中科院分区：
文献类型：
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作者：
T. Kume
Foxc1和Foxc2是Forkhead/Fox转录因子家族中关系密切的成员。这两种氧基因在发育过程中在中胚层和神经嵴衍生物中有重叠的表达模式，并且具有相似的基因调控功能。一直以来，每种基因的小鼠突变体在多个胚胎组织（包括眼睛、肾脏和心血管系统）中都有类似的异常。化合物foxc1分析；foxc2突变胚胎揭示了两个foxc2基因在发育过程中具有剂量依赖性和合作作用。特别是，最近的研究表明Foxc1和Foxc2对于动脉细胞分化、淋巴管形成、血管生成和心脏流出道发育至关重要。本章将总结和讨论目前关于Foxc1和Foxc2在心血管发育中的功能的知识。
Foxc1 and Foxc2 are closely related members of the Forkhead/Fox transcription factor family. The twoFoxcgenes have overlapping expression patterns in mesodermal and neural crest derivatives during development, as well as similar functions of gene regulation. Consistently, mouse mutants for each gene have similar abnormalities in multiple embryonic tissues, including the eye, kidney and cardiovascular system. Analysis of compoundFoxc1; Foxc2mutant embryos reveals that the twoFoxcgenes have dose-dependent, cooperative roles in development. In particular, recent studies demonstrate that Foxc1 and Foxc2 are essential for arterial cell specification, lymphatic vessel formation, angiogenesis and cardiac outflow tract development. This chapter will summarize and discuss current knowledge about the function of Foxc1 and Foxc2 in cardiovascular development.