Role of hydrogen sulfide in brain synaptic remodeling.
Role of hydrogen sulfide in brain synaptic remodeling.
复制标题
硫化氢在脑突触重塑中的作用。
DOI：
10.1016/bs.mie.2014.11.025
复制
发表时间：
2015
影响因子：
--
通讯作者：
Tyagi N
中科院分区：
文献类型：
--
作者：
Kamat PK;Kalani A;Tyagi N
突触是神经元之间的功能连接，是将电活动或化学活动从一个细胞转移到另一个细胞所必需的。突触由突触前膜和突触后膜形成，突触前膜和突触后膜在前神经元和后神经元之间进行通信，而神经化学调节剂在此过程中起作用。H2S是一种具有臭鸡蛋气味的有毒气体。然而，越来越多的研究表明，它对哺乳动物的多种生理和病理过程具有调节作用。因此，H2S是生理学上重要的分子，并且被称为与一氧化碳和一氧化氮一起的第三气体分子。上一个时代在H2S的生理和病理意义方面取得了指数发展。具体而言，在中枢神经系统中，H2S促进长时程增强并调节脑细胞中的细胞内钙浓度。我们以及其他人也表明，H2S具有抗氧化，抗凋亡和抗炎特性，可对抗各种神经退行性疾病，如中风，阿尔茨海默病和血管性痴呆。在这一章中，我们强调了目前的知识H2S和它的神经保护作用，特别强调突触重塑。
Synapses are the functional connection between neurons which are necessary for the transfer of electric activity or chemical activity from one cell to another. Synapses are formed by the pre- and postsynaptic membrane which communicates between pre- and postneurons while a neurochemical modulator is operated in this process. H2S has been known as a toxic gas with rotten eggs smell. However, increasing number of researches show that it regulate a variety of physiological and pathological processes in mammals. Hence, H2S is a physiologically important molecule and has been referred to as the third gaseous molecule alongside carbon monoxide and nitric oxide. The previous era has made an exponential development in the physiological and pathological significance of H2S. Specifically, in the central nervous system, H2S facilitates long-term potentiation and regulates intracellular calcium concentration in brain cells. We as well as others have also shown that H2S has antioxidant, antiapoptotic, and anti-inflammatory properties against various neurodegenerative disorders such as stroke, Alzheimer's disease, and vascular dementia. In this chapter, we highlight the current knowledge of H2S and its neuroprotective effects with a special emphasis on synaptic remodeling.