Synaptic dynamics and decision making
Synaptic dynamics and decision making
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DOI：
10.1073/pnas.1002333107
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发表时间：
2010-04-20
影响因子：
11.1
通讯作者：
Romo, Ranulfo
中科院分区：
文献类型：
--
作者：
Deco, Gustavo;Rolls, Edmund T.;Romo, Ranulfo
在对连续刺激进行决策时，必须先记住第一个刺激，然后再与第二个刺激进行比较。在这里，我们表明，在通过刺激的放电速率编码刺激的系统中，神经元不仅可以在延迟期间记住第一刺激，而且可以在第二刺激的呈现期间使用突触促进，以便它们对第一和第二刺激的组合做出反应，正如在振动触觉颤振频率决策过程中记录在腹侧运动前皮层的“部分差分”神经元所发现的那样。此外，我们表明，这种偏微分神经元为随后的吸引子决策网络提供了重要的输入，然后可以将第一和第二刺激的组合与仅对第二刺激作出反应的其他神经元的输入进行比较。因此，突触促进和神经元吸引子动力学都可以解释大脑中这些系统的顺序决策。
During decision making between sequential stimuli, the first stimulus must be held in memory and then compared with the second. Here, we show that in systems that encode the stimuli by their firing rate, neurons can use synaptic facilitation not only to remember the first stimulus during the delay but during the presentation of the second stimulus so that they respond to a combination of the first and second stimuli, as has been found for "partial differential" neurons recorded in the ventral premotor cortex during vibrotactile flutter frequency decision making. Moreover, we show that such partial differential neurons provide important input to a subsequent attractor decision-making network that can then compare this combination of the first and second stimuli with inputs from other neurons that respond only to the second stimulus. Thus, both synaptic facilitation and neuronal attractor dynamics can account for sequential decision making in such systems in the brain.