Atrial fibrillation: a major contributor to stroke in the elderly. The Framingham Study.
Atrial fibrillation: a major contributor to stroke in the elderly. The Framingham Study.
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DOI：
10.1001/archinte.1987.00370090041008
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发表时间：
1987-09
影响因子：
--
通讯作者：
P. Wolf;R. Abbott;W. Kannel
中科院分区：
文献类型：
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作者：
P. Wolf;R. Abbott;W. Kannel
无瓣膜病的慢性房颤与卒中发生率增加相关。在Frachial Heart研究中，对5184名男性和女性进行了房颤对中风风险随年龄增长的影响的研究。经过30年的随访，303人出现慢性房颤。年龄在30 - 39岁的人群中，乳腺癌特异性发病率从0.2/1000稳步上升至80 - 89岁的人群中的39.0/1000。与这种心律失常相关的卒中比例为14.7%，在总共462例初始卒中中有68例，随着年龄的增长而稳步增加，从50 - 59岁的6.7%增加到80 - 89岁的36.2%。与心力衰竭、冠心病和高血压的影响（随年龄增长而下降）相反，房颤是所有年龄段卒中的重要因素。
Chronic atrial fibrillation without valvular disease has been associated with increased stroke incidence. The impact of atrial fibrillation on the risk of stroke with increasing age was examined in 5184 men and women in the Framingham Heart Study. After 30 years of follow-up, chronic atrial fibrillation appeared in 303 persons. Age-specific incidence rates steadily increased from 0.2 per 1000 for ages 30 to 39 years to 39.0 per 1000 for ages 80 to 89 years. The proportion of strokes associated with this arrhythmia was 14.7%, 68 of the total 462 initial strokes, increasing steadily with age from 6.7% for ages 50 to 59 years to 36.2% for ages 80 to 89 years. In contrast to the impact of cardiac failure, coronary heart disease, and hypertension, which declined with age, atrial fibrillation was a significant contributor to stroke at all ages.