IN VIVO BEHAVIOR OF I131-FIBRINOGEN
IN VIVO BEHAVIOR OF I131-FIBRINOGEN
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DOI：
10.1172/jci104721
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发表时间：
1963-01-01
影响因子：
15.9
通讯作者：
MCFARLANE, AS
中科院分区：
文献类型：
--
作者：
MCFARLANE, AS
标记超过0.5个原子- i /分子的兔纤维蛋白原在受体动物血浆中的行为和同位素排泄率显示其部分变性。当0.5原子材料与cl4生物合成标记的纤维蛋白原一起注射时，蛋白质表现相同。在平衡状态下，体内80%的总标记纤维蛋白原在血液中，30-40%的血浆纤维蛋白原每天被分解代谢。如果已知碘的排泄率，则血浆中不可沉淀活性的比例可以很好地指示分解代谢率。只有少量皮下注射的标记纤维蛋白原进入血液，其余的分解代谢产生的活性迅速出现在尿液中。
Rabbit fibrinogen labeled with more than 0.5 atoms-I/molecule is partly denatured as shown by its behavior in the plasma of recipient animals and by rates of isotope excretion. When 0.5 atom material was injected along with Cl4-biosynthetically labeled fibrinogen the proteins behaved identically. At equilibrium 80% of the total labeled fibrinogen in the body was in the blood stream and 30-40% of the plasma fibrinogen was catabolised/day. Proportions of non-precipitable activity in the plasma gave a good indication of the catabolic rate if the excretion rate for iodide was known. Only small amounts of subcutaneously injected labeled fibrinogen passed into the blood stream and activity arising from catabolism of the remainder rapidly appeared in the urine.