Thymoquinone, as an anticancer molecule: from basic research to clinical investigation.
Thymoquinone, as an anticancer molecule: from basic research to clinical investigation.
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百里醌作为抗癌分子：从基础研究到临床研究
DOI：
10.18632/oncotarget.17206
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发表时间：
2017-08-01
期刊：
影响因子：
--
通讯作者：
Fu J
中科院分区：
文献类型：
--
作者：
Asaduzzaman Khan M;Tania M;Fu S;Fu J
Thymoquinone is an anticancer phytochemical commonly found in black cumin. In this review, we discuss the potential of thymoquinone as anticancer molecule, its mechanism of action and future usage in clinical applications. Thymoquinone exhibits anticancer activity via numerous mechanisms of action, specifically by showing selective antioxidant and oxidant activity, interfering with DNA structure, affecting carcinogenic signaling molecules/pathways and immunomodulation. In vitro activity of thymoquinone has been further implicated in animal models of cancer; however, no clinical application has been proven yet. This is the optimum time to focus on clinical trials for developing thymoquinone as a future drug in cancer therapeutics.
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