Visceral Adiposity Index Is Associated with Insulin Sensitivity and Adipocytokine Levels in Newly Diagnosed Acromegalic Patients
Visceral Adiposity Index Is Associated with Insulin Sensitivity and Adipocytokine Levels in Newly Diagnosed Acromegalic Patients
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DOI：
10.1210/jc.2012-1518
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发表时间：
2012-08-01
影响因子：
5.8
通讯作者：
Galluzzo, C. Giordano
中科院分区：
文献类型：
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作者：
Ciresi, A.;Amato, M. C.;Galluzzo, C. Giordano
背景：内脏脂肪指数（VAI）已被证明是内脏脂肪功能障碍的标志，在一般和特定人群的代谢风险患者中与胰岛素敏感性密切相关。目的：本研究的目的是测试VAI作为评估肢端肥大症早期代谢风险的有用工具。患者：24例新诊断肢端肥大症患者（女11例，男13例，年龄54.9±13.6岁）分为正常组（A组，n = 13, 54.2%）和高VAI组（B组，n = 11, 45.8%）。观察指标：口服糖耐量试验期间血糖、血红蛋白A1c、生长激素曲线下最低点和曲线下面积（AUC） （AUC(GH)）、混合膳食耐量试验期间AUC（肽）、正糖-高胰岛素钳夹期间M值、口服体质指数（DIo）、代谢综合征各组分、瘦素、脂联素、tnf - α和IL-6。结果：VAI值与患者年龄（rho = 0.408, P = 0.048）、肿瘤体积（rho = 0.638, P = 0.001）、基础GH （rho = 0.622, P = 0.001）、最低GH （rho = 0.534, P = 0.007）、AUC(GH) （rho = 0.603, P = 0.002）、IGF-I （rho = 0.618, P = 0.001）、tnf - α (rho = 0.512, P = 0.010)、AUC(Cpeptide) （rho = 0.715, P = 0.001）呈正相关
Context: The visceral adiposity index (VAI) has proved to be a marker of visceral adipose dysfunction, strongly associated with insulin sensitivity in both the general and specific populations of patients at metabolic risk.Objective: The objective of the study was to test VAI as a useful tool to assess early metabolic risk in acromegaly.Patients: Twenty-four newly diagnosed acromegalic patients (11 women and 13 men, aged 54.9 +/- 13.6 yr) were grouped into those with normal (group A, n = 13, 54.2%) and those with high VAI (group B, n = 11, 45.8%).Outcome Measures: Glucose, hemoglobin A1c, nadir and area under the curve (AUC) of GH (AUC(GH)) during the oral glucose tolerance test, AUC(Cpeptide) during a mixed-meal tolerance test, M value during euglycemic-hyperinsulinemic clamp, oral dispositional index (DIo), each component of the metabolic syndrome, leptin, adiponectin, TNF-alpha, and IL-6.Results: The VAI value was positively correlated with the age of patients (rho = 0.408; P = 0.048), tumor volume (rho = 0.638; P = 0.001), basal GH (rho = 0.622; P = 0.001), nadir GH (rho = 0.534; P = 0.007), AUC(GH) (rho = 0.603; P = 0.002), IGF-I (rho = 0.618; P = 0.001), TNF-alpha (rho = 0.512; P = 0.010), and AUC(Cpeptide) (rho = 0.715; p