Asymptomatic and Submicroscopic Carriage of Plasmodium knowlesi Malaria in Household and Community Members of Clinical Cases in Sabah, Malaysia
Asymptomatic and Submicroscopic Carriage of Plasmodium knowlesi Malaria in Household and Community Members of Clinical Cases in Sabah, Malaysia
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DOI：
10.1093/infdis/jiv475
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发表时间：
2016-03-01
影响因子：
6.4
通讯作者：
Drakeley, Chris J.
中科院分区：
文献类型：
--
作者：
Fornace, Kimberly M.;Nuin, Nor Afizah;Drakeley, Chris J.
尽管人类疟疾物种无症状携带的情况已被广泛报道，但无症状、亚显微诺氏疟原虫寄生虫血症的程度尚不清楚。在这项研究中，样本是从居住在有症状的疟疾病例的家庭或村庄的个人中获取的，目的是检测该人群中的亚显微诺氏疟原虫。四项已发表的分子测定被用来确认诺氏疟原虫的存在。潜在类别分析显示，无症状个体的估计比例为 6.9%（95% 置信区间，5.6%-8.4%）。这项研究证实，所有年龄段都存在大量无症状单一感染；需要进一步开展工作来估计更广泛社区的患病率。
Although asymptomatic carriage of human malaria species has been widely reported, the extent of asymptomatic, submicroscopic Plasmodium knowlesi parasitemia is unknown. In this study, samples were obtained from individuals residing in households or villages of symptomatic malaria cases with the aim of detecting submicroscopic P. knowlesi in this population. Four published molecular assays were used to confirm the presence of P. knowlesi. Latent class analysis revealed that the estimated proportion of asymptomatic individuals was 6.9% (95% confidence interval, 5.6%-8.4%). This study confirms the presence of a substantial number of asymptomatic monoinfections across all age groups; further work is needed to estimate prevalence in the wider community.