The Role of Type 1 Conventional Dendritic Cells in Cancer Immunity.
The Role of Type 1 Conventional Dendritic Cells in Cancer Immunity.
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DOI：
10.1016/j.trecan.2018.09.001
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发表时间：
2018-11
期刊：
影响因子：
18.4
通讯作者：
Reis e Sousa C
中科院分区：
文献类型：
--
作者：
Böttcher JP;Reis e Sousa C
树突状细胞（DC）是免疫应答的关键协调者。一个特定的DC亚群，传统的1型DC（cDC1），最近已与人类癌症患者的生存，并在临床前模型，是自发排斥免疫原性癌症和T细胞为基础的免疫治疗的成功至关重要。cDC 1的独特作用反映了在迁移到肿瘤引流淋巴结后启动从头T细胞应答的能力，以及吸引T细胞、分泌细胞因子和在肿瘤微环境内呈递肿瘤抗原的能力，从而增强局部细胞毒性T细胞功能。旨在增加肿瘤中cDC 1丰度并增强其功能的策略为增强抗肿瘤免疫力和克服对癌症免疫疗法的抗性提供了有吸引力的新途径。传统的1型树突状细胞（cDC1）是一种特殊的DC亚群，在癌症免疫控制中具有独特的作用。免疫原性癌症的排斥和基于T细胞的免疫疗法在临床前模型中的成功需要功能性cDC1。在人类癌症患者中，肿瘤组织中的cDC 1丰度与癌症患者的生存率和对免疫检查点阻断的反应性相关。cDC1进入肿瘤组织受到严格调控，并涉及肿瘤内淋巴细胞（如自然杀伤细胞）的趋化因子分泌。肿瘤源性因子通过限制cDC 1在肿瘤微环境中的积累、生存和功能来损害抗肿瘤免疫力。
Dendritic cells (DCs) are key orchestrators of immune responses. A specific DC subset, conventional type 1 DCs (cDC1s), has been recently associated with human cancer patient survival and, in preclinical models, is critical for the spontaneous rejection of immunogenic cancers and for the success of T cell–based immunotherapies. The unique role of cDC1 reflects the ability to initiate de novo T cell responses after migrating to tumor-draining lymph nodes, as well as to attract T cells, secrete cytokines, and present tumor antigens within the tumor microenvironment, enhancing local cytotoxic T cell function. Strategies aimed at increasing cDC1 abundance in tumors and enhancing their functionality provide attractive new avenues to boost anti-tumor immunity and overcome resistance to cancer immunotherapies. Conventional type 1 dendritic cells (cDC1s) are a specialized subset of DCs with a unique role in cancer immune control. Rejection of immunogenic cancers and the success of T cell–based immunotherapies in preclinical models requires functional cDC1s. In human cancer patients, cDC1 abundance in tumor tissue is associated with cancer patient survival and the responsiveness to immune checkpoint blockade. The access of cDC1s to tumor tissue is tightly regulated and involves chemokine secretion from intratumoral lymphocytes such as natural killer cells. Tumor-derived factors impair anti-tumor immunity by limiting cDC1 accumulation, survival, and function within the tumor microenvironment.