Learning decision thresholds for risk stratification models from aggregate clinician behavior.

Learning decision thresholds for risk stratification models from aggregate clinician behavior.
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DOI:
10.1093/jamia/ocab159
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发表时间:
2021-09-18
期刊:
Journal of the American Medical Informatics Association : JAMIA
影响因子:
--
通讯作者:
Shah NH
Shah NH
中科院分区:
其他
文献类型:
--
作者:
Patel BS;Steinberg E;Pfohl SR;Shah NH

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Using a risk stratification model to guide clinical practice often requires the choice of a cutoff—called the decision threshold—on the model’s output to trigger a subsequent action such as an electronic alert. Choosing this cutoff is not always straightforward. We propose a flexible approach that leverages the collective information in treatment decisions made in real life to learn reference decision thresholds from physician practice. Using the example of prescribing a statin for primary prevention of cardiovascular disease based on 10-year risk calculated by the 2013 pooled cohort equations, we demonstrate the feasibility of using real-world data to learn the implicit decision threshold that reflects existing physician behavior. Learning a decision threshold in this manner allows for evaluation of a proposed operating point against the threshold reflective of the community standard of care. Furthermore, this approach can be used to monitor and audit model-guided clinical decision making following model deployment.
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