Tumor hypoxia and microscopic diffusion capacity in brain tumors: a comparison of (62)Cu-Diacetyl-Bis (N4-Methylthiosemicarbazone) PET/CT and diffusion-weighted MR imaging.
Tumor hypoxia and microscopic diffusion capacity in brain tumors: a comparison of (62)Cu-Diacetyl-Bis (N4-Methylthiosemicarbazone) PET/CT and diffusion-weighted MR imaging.
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脑肿瘤中的肿瘤缺氧和显微扩散能力：(62)Cu-二乙酰基-双（N4-甲硫缩氨基脲）PET/CT 和扩散加权 MR 成像的比较。
DOI：
10.1007/s00259-014-2714-x
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Inoue T
中科院分区：
文献类型：
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作者：
Hino-Shishikura A;Tateishi U;Shibata H;Yoneyama T;Nishii T;Torii I;Tateishi K;Ohtake M;Kawahara N;Inoue T
本研究的目的是通过对34例低级别胶质瘤(LGG，n= 13)、胶质母细胞瘤(GbM，n= 20)和原发性中枢神经系统淋巴瘤(PCSL，n=DNSL)进行62CuATSMPET/CT和弥散加权成像，以明确肿瘤缺氧与显微弥散能力之间的关系。结果62Cu-ATSMPET/CT和弥散系数在 和PCNSL患者中呈高信号，而在LGG患者中呈低信号。所有肿瘤的最大SUV(SUVmax)与最小ADCmin(r= −0.583，p<； 0.0001)、肿瘤/脑比值(T/B)与ADCmin(r= −0.532，p<； 0.0001)呈负相关。GBM的SUVmax和T/Batioin均高于IGG(p<； 0.0001和p<； 0.0001)，PCNSL也高于GBM(p= 0.033和p= 0.044)。GBM(p= 0.011)和PCNSL(p= 0.0 1)的ADCmin值均低于正常脑组织(p= 0.0 1)，而GBM和PCNSL之间差异无统计学意义(p=DWI 0.90)。62Cu-ATSM PET/CT和DWI均被认为是脑胶质瘤分级的可行影像方法。然而，62Cu-ATSM PET/CT为鉴别GBM和PCNSL提供了额外的诊断信息。
ObjectivesThe aim of this study was to clarify the relationship between tumor hypoxia and microscopic diffusion capacity in primary brain tumors using62Cu-Diacetyl-Bis (N4-Methylthiosemicarbazone) (62Cu-ATSM) PET/CT and diffusion-weighted MR imaging (DWI).MethodsThis study was approved by the institutional human research committee and was HIPAA compliant, and informed consent was obtained from all patients.62Cu-ATSM PET/CT and DWI were performed in a total of 40 primary brain tumors of 34 patients with low grade glioma (LGG,n= 13), glioblastoma (GBM,n= 20), and primary central nervous system lymphoma (PCNSL,n= 7).62Cu-ATSM PET/CT parameters and apparent diffusion coefficient (ADC) obtained by DWI were compared.ResultsHigh intensity signals by62Cu-ATSM PET/CT and DWI in patients with GBM and PCNSL, and low intensity signals in LGG patients were observed. An inverse correlation was found between maximum SUV (SUVmax) and minimum ADC (ADCmin) (r= −0.583,p< 0.0001), and between tumor/brain ratio (T/Bratio) and ADCminfor all tumors (r= −0.532,p< 0.0001). Both SUVmaxand T/Bratioin GBM were higher than LGG (p< 0.0001 andp< 0.0001), and those in PCNSL were also higher than GBM (p= 0.033 andp= 0.044). The ADCminwas lower in GBM (p= 0.011) and PCNSL (p= 0.01) than in LGG, while no significant difference was found between GBM and PCNSL (p= 0.90).ConclusionTumor hypoxia assessed by62Cu-ATSM PET/CT correlated with microscopic diffusion capacity obtained by DWI in brain tumors. Both62Cu-ATSM PET/CT and DWI were considered feasible imaging methods for grading glioma. However,62Cu-ATSM PET/CT provided additional diagnostic information to differentiate between GBM and PCNSL.