Biosynthesis of the RNA Polymerase Inhibitor Streptolydigin in Streptomyces lydicus: Tailoring Modification of 3-Methyl-Aspartate
Biosynthesis of the RNA Polymerase Inhibitor Streptolydigin in Streptomyces lydicus: Tailoring Modification of 3-Methyl-Aspartate
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DOI：
10.1128/jb.00108-11
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发表时间：
2011-05-01
影响因子：
3.2
通讯作者：
Salas, Jose A.
中科院分区：
文献类型：
--
作者：
Horna, Dina H.;Gomez, Cristina;Salas, Jose A.
天冬酰胺酰-tRNA合成酶样SlgZ和甲基转移酶SlgM酶参与利迪链霉菌中特特拉姆酸链霉利地金的生物合成。slgZ的失活导致新的利迪菌素衍生物。在S. Lydicus导致溶血链球菌素产量的显著增加。
The asparaginyl-tRNA synthetase-like SlgZ and methyltransferase SlgM enzymes are involved in the biosynthesis of the tetramic acid streptolydigin in Streptomyces lydicus. Inactivation of slgZ led to a novel streptolydigin derivative. Overexpression of slgZ, slgM, or both in S. lydicus led to a considerable increase in streptolydigin production.