Replacement Effects of Sedentary Time on Metabolic Outcomes: The Maastricht Study
Replacement Effects of Sedentary Time on Metabolic Outcomes: The Maastricht Study
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DOI：
10.1249/mss.0000000000001248
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发表时间：
2017-07-01
期刊：
影响因子：
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通讯作者：
Koster, Annemarie
中科院分区：
文献类型：
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作者：
Van Der Berg, Julianne D.;Van Der Velde, Jeroenh. P. M.;Koster, Annemarie
简介：久坐时间与有害健康的影响有关，因此在一些国家，已经制定了减少久坐时间的指南。由于减少久坐时间不可避免地会导致更多的非久坐时间，这种减少的效果可能取决于替代它的活动。目的：本研究旨在研究理论上将久坐时间重新分配为站立或踏步与心脏代谢结果和2型糖尿病之间的关系。研究方法：我们纳入了马斯特里赫特研究的2213名参与者（51%为男性，平均+/- SD年龄= 60.0 +/- 8.1岁），要求他们佩戴加速度计24 h.d（-1），持续一周。我们计算了每天久坐、站立和步行的时间。应用等时替代建模方法研究对腰围、体重指数、胆固醇、三酰甘油、葡萄糖和胰岛素水平、代谢综合征和2型糖尿病的影响。结果如下：替代久坐时间（30 min.d（-1））与代谢综合征发生率较低相关（比值比[OR] = 0.72，95%置信区间[CI] = 0.66-0.78）和2型糖尿病（OR = 0.79，95%CI = 0.72-0.87），腰围更有利（B =-1.42，95% CI = -1.78至-1.06）和体重指数（B =-0.48，95% CI = -0.62至-0.35），并改善胆固醇、三酰甘油、葡萄糖和胰岛素水平。用站立取代久坐时间与代谢综合征和2型糖尿病的低风险相关，并且在腰围、胆固醇、三酰甘油和胰岛素水平方面具有良好的结果。结论：理论上，用非久坐时间（站立和踏步）替代久坐时间与代谢综合征、2型糖尿病和有益的代谢结果的几率较低相关。这些结果对一般人群可能很重要，包括那些不能满足体力活动指南的人。应考虑制定建议，重新分配每天的久坐时间。
Introduction: Sedentary time has been associated with detrimental health effects, so in some countries, guidelines to reduce sedentary time have been developed. As reducing sedentary time inevitably results in more nonsedentary time, effects of this reduction may depend on the activity with which it is replaced. Purpose: This study aimed to examine associations of theoretical reallocations of sedentary time to standing or stepping with cardiometabolic outcomes and type 2 diabetes. Methods: We included 2213 participants (51% men, mean +/- SD age = 60.0 +/- 8.1 yr) of the Maastricht Study who were asked to wear an accelerometer 24 h.d(-1) for a week. We calculated daily sedentary, standing, and stepping time. An isotemporal substitution modeling approach was applied to examine effects on waist circumference; body mass index; cholesterol, triacylglycerol, glucose, and insulin levels; metabolic syndrome; and type 2 diabetes. Results: Replacement of sedentary time (30 min.d(-1)) with stepping was associated with lower odds for metabolic syndrome (odds ratio [OR] = 0.72, 95% confidence interval [CI] = 0.66-0.78) and type 2 diabetes (OR = 0.79, 95% CI = 0.72-0.87), more favorable waist circumference (B = -1.42, 95% CI = -1.78 to -1.06), and body mass index (B = -0.48, 95% CI = -0.62 to -0.35) and improved cholesterol, triacylglycerol, glucose, and insulin levels. Replacing sedentary time with standing was associated with lower odds for metabolic syndrome and type 2 diabetes and favorable outcomes in waist circumference, cholesterol, triacylglycerol, and insulin levels. Conclusion: Theoretical replacements of sedentary time with nonsedentary time (both standing and stepping) were associated with lower odds for metabolic syndrome, type 2 diabetes, and beneficial metabolic outcomes. These results could be important for the general population, including those who cannot meet physical activity guidelines. Consideration should be given to developing recommendations for daily reallocating sedentary time.