Functional significance of macrophages in pancreatic cancer biology.
Functional significance of macrophages in pancreatic cancer biology.
复制标题
巨噬细胞在胰腺癌生物学中的功能意义。
DOI：
10.1007/s13277-015-4127-2
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发表时间：
2015-12
期刊：
影响因子：
--
通讯作者：
Wang LW
中科院分区：
文献类型：
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作者：
Hu H;Jiao F;Han T;Wang LW
胰腺导管腺癌（PDA）是一种致死性疾病，通常诊断为晚期，有效的治疗方法很少。尽管肿瘤细胞的基因组学和蛋白质组学取得了快速进展，但针对胰腺癌细胞的治疗被证明是无效的，这促使研究人员将注意力转向微环境。目前，各种研究提出微环境是PDA的一个促成因素，广泛的研究表明，恶性肿瘤内的巨噬细胞与疾病的恶性表型相关，并被报道为一个新的治疗靶点。巨噬细胞的促肿瘤作用可概括为促血管生成、免疫抑制、基质重塑等，因此，全面了解巨噬细胞的生物学行为及其在PDA发生发展中的重要作用，将为这一致死性疾病的治疗提供新的方向。在这篇综述中，我们将总结巨噬细胞作为PDA生物学中的关键参与者的最新进展，以及目前关于抗巨噬细胞作为抗癌新策略的知识，并期望在不久的将来开发出更有效的治疗方法。
Pancreatic ductal adenocarcinoma (PDA) is a lethal disease that is usually diagnosed at late stage with few effective therapies. Despite the rapid progress on the genomics and proteomics of the neoplastic cells, therapies that targeted the pancreatic cancer cells proved to be inefficient, which promoted the researchers to turn their attentions to the microenvironment. Currently, various studies had proposed the microenvironment to be a contributing factor for PDA and pervasive researches showed that macrophages within the malignancy correlate with the malignant phenotype of the disease and were reported to a new therapeutic target. Generally, the pro-tumoral effects of macrophages can be summarized as angiogenesis promotion, immunosuppression, matrix remodeling and so on. Hence, a comprehensive understanding of the biologic behaviors of macrophages and their critical role in PDA development may provide new directions for the managements of the lethal disease. In this review, we will summarize the recent advancements on macrophages as pivotal players in PDA biology and the current knowledge about anti-macrophages as a novel strategy against cancer, with the expectation that more efficient therapies will be developed in the near future.