Association between the serotonin transporter and cytokines: Implications for the pathophysiology of bipolar disorder
Association between the serotonin transporter and cytokines: Implications for the pathophysiology of bipolar disorder
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DOI：
10.1016/j.jad.2015.10.056
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发表时间：
2016-02-01
影响因子：
6.6
通讯作者：
Wang, Shyh-Jen
中科院分区：
文献类型：
--
作者：
Chou, Yuan-Hwa;Hsieh, Wen-Chi;Wang, Shyh-Jen
背景：脑5 -羟色胺转运体（SERT）减少已在双相情感障碍（BD）中得到证实。本研究的目的是探讨细胞因子在BD患者SERT降低中的潜在作用。方法：招募28例BD I型患者和28例年龄和性别匹配的健康对照（hc）。单光子发射计算机断层扫描与放射性示踪剂1231 ADAM用于SERT成像。感兴趣的区域包括中脑、丘脑、壳核和尾状核。采用酶联免疫吸附法测定7种细胞因子，包括肿瘤坏死因子- α (tnf - α)、干扰素- γ (ifn - γ)、白细胞介素-1 α (IL-1 α)、IL-1 β、IL-4、IL-6和IL-10。结果：与hcc相比，BD患者中脑和尾状核的SERT可用性显著降低。与hcc相比，BD中IL-1 β显著降低，而IL-10显著升高。多元线性回归分析显示，细胞因子、IL-1 α、IL-1 β、IL-6和SERT有效性在中脑存在相关性，而在丘脑、壳核和尾状核中不存在相关性。此外，线性混合效应分析表明，这些关联在hcc和BD之间没有差异。结论：虽然许多细胞因子在BD的病理生理中起重要作用，但我们的研究结果表明，细胞因子和SERT可用性之间的显著关联可能解释了细胞因子在情绪调节中的作用。然而，这些关联在hcc和BD之间并没有不同，这意味着这些细胞因子的作用不是BD所特有的。(C) 2015 Elsevier B.V.版权所有。
Background: Reduced brain serotonin transporter (SERT) has been demonstrated in bipolar disorder (BD). The aim of this study was to explore the potential role of cytokines on reduced SERT in BD.Methods: Twenty-eight BD type I patients and 28 age- and gender-matched healthy controls (HCs) were recruited. Single photon emission computed tomography with the radiotracer 1231 ADAM was used for SERT imaging. Regions of interest included the midbrain, thalamus, putamen and caudate. Seven cytokines, including tumor necrosis factor-alpha (TNIF-alpha), interferon-gamma (IFN-gamma), interleukin-1 alpha (IL-1 alpha), IL-1 beta, IL-4, IL-6 and IL-10, were measured using an enzyme linked immune-sorbent assay. Results: SERT availability in the midbrain and caudate was significantly lower in BD compared to HCs. IL-1 beta was significantly lower, whereas IL-10 was significantly higher in BD compared to HCs. Multiple linear regression analyses revealed that there were associations between cytokines, IL-1 alpha, IL-1 beta, IL-6 and SERT availability in the midbrain but not in the thalamus, putamen and caudate. Furthermore, linear mixed effect analyses demonstrated that these associations were not different between HCs and BD.Conclusion: While many cytokines have been proposed to be important in the pathophysiology of BD, our results demonstrated that significant associations between cytokines and SERT availability may explain the role of cytokines in mood regulation. However, these associations were not different between HCs and BD, which imply the role of these cytokines is not specific for BD. (C) 2015 Elsevier B.V. All rights reserved.